E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 88
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Original Article
Online Published: 07 Nov 2025
 


Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs

Mohamed S. Hamed, Mahmoud M. Ismael, Ali M. Metwally, Magda S. El-sayed, Samir El-zarkouny, Hebatallah M. Saad, Ibrahim A. Abdullaziz.


Abstract
The present study was designed to evaluate the clinical, hematobiochemical, and histopathological alterations associated with doxorubicin-induced cardiomyopathy in dogs. A total number of twelve clinically healthy adult Egyptian street dogs were involved in this study and evaluated two times (immediately prior to the first doxorubicin dose "baseline" while the second time "final evaluation" was after administration of the sixth "final" dose of doxorubicin). Our obtained data showed numerical reduction of total RBCs count, Hb content and PCV% and significant reduction of total WBCs count value in the final evaluation compared to baseline one. On the other hand, there were a significant elevation of NT-proBNP and cardiac troponin I value in the final evaluation compared to baseline one. additionally histopathological evaluation revealed myocardial vacuolization, congestion, hemorrhage, degeneration and fibrotic changes in doxorubicin-treated dogs. In conclusions, the doxorubicin was linked to a sharper decline in total WBCs count levels due to its potent myelosuppression effect associated with more prominent myocardial degenerative lesions. Moreover, NT-proBNP and cardiac troponin I could be useful in the pre-clinical diagnosis of cardiomyopathy in dogs.

Key words: Dilated cardiomyopathy; Doxorubicin, NT-proBNP, cardiac troponin I, Doxorubicin induced cardiomyopathy.


 
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How to Cite this Article
Pubmed Style

Hamed MS, Ismael MM, Metwally AM, El-sayed MS, El-zarkouny S, Saad HM, Abdullaziz IA. Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. AJVS. 2026; 88(0): 235-243. doi:10.5455/ajvs.292103

Web Style

Hamed MS, Ismael MM, Metwally AM, El-sayed MS, El-zarkouny S, Saad HM, Abdullaziz IA. Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. https://www.alexjvs.com/?mno=292103 [Access: February 04, 2026]. doi:10.5455/ajvs.292103

AMA (American Medical Association) Style

Hamed MS, Ismael MM, Metwally AM, El-sayed MS, El-zarkouny S, Saad HM, Abdullaziz IA. Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. AJVS. 2026; 88(0): 235-243. doi:10.5455/ajvs.292103


Vancouver/ICMJE Style

Hamed MS, Ismael MM, Metwally AM, El-sayed MS, El-zarkouny S, Saad HM, Abdullaziz IA. Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. AJVS. (2026), [cited February 04, 2026]; 88(0): 235-243. doi:10.5455/ajvs.292103


Harvard Style

Hamed, M. S., Ismael, . M. M., Metwally, . A. M., El-sayed, . M. S., El-zarkouny, . S., Saad, . H. M. & Abdullaziz, . I. A. (2026) Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. AJVS, 88 (0), 235-243. doi:10.5455/ajvs.292103


Turabian Style

Hamed, Mohamed S., Mahmoud M. Ismael, Ali M. Metwally, Magda S. El-sayed, Samir El-zarkouny, Hebatallah M. Saad, and Ibrahim A. Abdullaziz. 2026. Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. Alexandria Journal of Veterinary Sciences, 88 (0), 235-243. doi:10.5455/ajvs.292103


Chicago Style

Hamed, Mohamed S., Mahmoud M. Ismael, Ali M. Metwally, Magda S. El-sayed, Samir El-zarkouny, Hebatallah M. Saad, and Ibrahim A. Abdullaziz. "Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs." Alexandria Journal of Veterinary Sciences 88 (2026), 235-243. doi:10.5455/ajvs.292103


MLA (The Modern Language Association) Style

Hamed, Mohamed S., Mahmoud M. Ismael, Ali M. Metwally, Magda S. El-sayed, Samir El-zarkouny, Hebatallah M. Saad, and Ibrahim A. Abdullaziz. "Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs." Alexandria Journal of Veterinary Sciences 88.0 (2026), 235-243. Print. doi:10.5455/ajvs.292103


APA (American Psychological Association) Style

Hamed, M. S., Ismael, . M. M., Metwally, . A. M., El-sayed, . M. S., El-zarkouny, . S., Saad, . H. M. & Abdullaziz, . I. A. (2026) Clinical, Hematobiochemical and Histopathological Alterations in Doxorubicin Induced Cardiomyopathy in Dogs. Alexandria Journal of Veterinary Sciences, 88 (0), 235-243. doi:10.5455/ajvs.292103




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Alexandria University
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    Egypt.

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