E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 80, Issue: 1
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Original Article

Online Publishing Date:
31 / 03 / 2024

 


Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity

Nesma Soliman, Reham Fahmy, Mohamed El-Adl.


Abstract
The current study was conducted to evaluate the cardioprotective potentials of eugenol against hypertension induced by doxorubicin in rats. Rats were exposed to Doxorubicin HCl (2mg/kg body weight) intraperitoneally to induce cardiotoxicity and treated with eugenol (5 mg/kg) orally for 5 weeks. At the end of the study, the blood pressure was assessed in the tested animals and the levels of serum lipid profile and oxidative stress markers were assessed. Also, the heart was dissected and the oxidative stress and apoptotic markers in heart homogenate were assessed. There was high statistically significant difference between all the tested groups regarding the systolic blood pressure and mean arterial pressure. The Serum oxidative stress markers and lipid profile markers showed a statistically significant increase in the positive control group compared to other groups. The heart homogenate level of all the tested parameters showed a statistically significant increase in the positive group compared to other groups except for the MDA levels that was comparable between the positive group and protection group. Eugenol's antioxidant and lipid-lowering properties protect against hypertension. Eugenol's antioxidant and anti-apoptotic effects protect the heart from hypertension's long-term effects at the tissue level.

Key words: Hypertension, eugenol, Doxorubicin, Apoptosis, Oxidative stress, Rats.


 
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Pubmed Style

Soliman N, Fahmy R, El-Adl M, . Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. AJVS. Online First: 31 Mar, 2024.

Web Style

Soliman N, Fahmy R, El-Adl M, . Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. https://www.alexjvs.com/?mno=191287 [Access: April 06, 2024].

AMA (American Medical Association) Style

Soliman N, Fahmy R, El-Adl M, . Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. AJVS. Online First: 31 Mar, 2024.


Vancouver/ICMJE Style

Soliman N, Fahmy R, El-Adl M, . Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. AJVS, [cited April 06, 2024]; Online First: 31 Mar, 2024.


Harvard Style

Soliman, N., Fahmy, R., El-Adl, M. & (0) Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. AJVS, Online First: 31 Mar, 2024.


Turabian Style

Soliman, Nesma, Reham Fahmy, Mohamed El-Adl, and . 0. Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. Alexandria Journal of Veterinary Sciences, Online First: 31 Mar, 2024.


Chicago Style

Soliman, Nesma, Reham Fahmy, Mohamed El-Adl, and . "Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity." Alexandria Journal of Veterinary Sciences Online First: 31 Mar, 2024.


MLA (The Modern Language Association) Style

Soliman, Nesma, Reham Fahmy, Mohamed El-Adl, and . "Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity." Alexandria Journal of Veterinary Sciences Online First: 31 Mar, 2024. Web. 06 Apr 2024


APA (American Psychological Association) Style

Soliman, N., Fahmy, R., El-Adl, M. & (0) Eugenol improved antioxidant status, proinflammatory and apoptotic markers on rats exposed to cardiotoxicity. Alexandria Journal of Veterinary Sciences, Online First: 31 Mar, 2024.




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