Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups

Mahmoud A. Khedr; Mohamed A. Mandour; Rashed R. Rashed; Amira A. Goma; Sara E. El-kazaz

doi:10.5455/ajvs.107008

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Original Article
Online Published: 01 Jul 2020

AJVS. 2020; 66(1): 36-44

doi: 10.5455/ajvs.107008

Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups

Mahmoud A. Khedr, Mohamed A. Mandour, Rashed R. Rashed, Amira A. Goma, Sara E. El-kazaz.

Abstract
Zinc is involved in many protein structures, which had a role in some neurological functions. The present study was designed to investigate the effect of zinc oxide nanoparticles and its conventional one on memory and learning ability of adult male rats and their offspring. Thirty adult male rats were randomly distributed into 5 groups (6 rats, each). First group (control group) was injected with Tween 80 (10%), second and third groups, received two doses of Zinc oxide nanoparticles (ZnONPs), 5 and 10 mg/kg bwt respectively. Fourth and fifth groups, administrated two doses of conventional Zinc oxide (CZnO), 5 and 10 mg/kg bwt, respectively. Rats in all groups were injected intraperitoneally by 1ml/rat for 16 days period, every other day. A series of neurobehavioural tests including open field, elevated plus maze and Morris water maze test were conducted. The obtained results indicated that the ZnONPs lower dose improved locomotor behaviour during open field test and had an anxiolytic effect in the elevated plus maze, but higher doses were not beneficial. It can be concluded that the zinc oxide nanoparticles are better than conventional zinc oxide.

Key words: Zinc oxide nanoparticles, Conventional Zinc oxide, learning ability, memory, locomotor behaviour, anxiety.

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Pubmed Style

Khedr MA, Mandour MA, Rashed RR, Goma AA, El-kazaz SE. Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. AJVS. 2020; 66(1): 36-44. doi:10.5455/ajvs.107008

Web Style

Khedr MA, Mandour MA, Rashed RR, Goma AA, El-kazaz SE. Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. https://www.alexjvs.com/?mno=107008 [Access: May 06, 2025]. doi:10.5455/ajvs.107008

AMA (American Medical Association) Style

Khedr MA, Mandour MA, Rashed RR, Goma AA, El-kazaz SE. Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. AJVS. 2020; 66(1): 36-44. doi:10.5455/ajvs.107008

Vancouver/ICMJE Style

Khedr MA, Mandour MA, Rashed RR, Goma AA, El-kazaz SE. Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. AJVS. (2020), [cited May 06, 2025]; 66(1): 36-44. doi:10.5455/ajvs.107008

Harvard Style

Khedr, M. A., Mandour, . M. A., Rashed, . R. R., Goma, . A. A. & El-kazaz, . S. E. (2020) Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. AJVS, 66 (1), 36-44. doi:10.5455/ajvs.107008

Turabian Style

Khedr, Mahmoud A., Mohamed A. Mandour, Rashed R. Rashed, Amira A. Goma, and Sara E. El-kazaz. 2020. Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups. Alexandria Journal of Veterinary Sciences, 66 (1), 36-44. doi:10.5455/ajvs.107008

Chicago Style

Khedr, Mahmoud A., Mohamed A. Mandour, Rashed R. Rashed, Amira A. Goma, and Sara E. El-kazaz. "Neurobehavioural Effect of Zinc Oxide Nanoparticles and its Conventional Form on Adult Male Rats and Their Pups." Alexandria Journal of Veterinary Sciences 66 (2020), 36-44. doi:10.5455/ajvs.107008

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APA (American Psychological Association) Style

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