E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats

Hebatallah M. Saad, Samah S. Oda, Eman K. Sedeek.

Abstract
The present study was designed to investigate the protective effect of lactéol® forte against thioacetamide (TAA)-induced hepatic damage in rats. Twenty male albino rats were randomly allocated into four groups (five rats each) as followed control group: received 0.2 ml of distilled water/ 100 g B.W./ day orally 5 times/week, TAA-treated group: received an intraperitoneal injection (I/P) of TAA at a dose of 200 mg/kg B.W. twice/ week, Lactéal fort-treated group: received lactéal fort (1 × 109 CFU/rat) orally 5 times/week, and TAA + Lactéal fort: I/P injected with TAA (200 mg/kg B.W.) and lactéal fort was given orally (1 × 109 CFU/rat). Six weeks post-treatment, biochemical results indicated that TAA induced a significant elevation in the serum level of aspartate aminotransferase AST and no significant difference was observed in serum levels of alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) as compared to control. While, no significant changes in serum levels of hepatic enzymes (ALT, AST, and GGT) were recorded. Histopathologically, TAA induced various degenerative, necrotic, fibroblastic and hyperplastic alterations. Conversely, the administration of lactéol® forte improved TAA-induced hepatic histopathologic alterations. In conclusion, lactéol® forte improved serum liver enzymes and liver damage, suggesting it to have useful protective potential against liver injury.

Key words: Thioactamide, Lactéol® forte, Liver, Rats, Histopathology.


 
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How to Cite this Article
Pubmed Style

Saad HM, Oda SS, Sedeek EK. Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. AJVS. 2020; 67(1): 92-98. doi:10.5455/ajvs.17323


Web Style

Saad HM, Oda SS, Sedeek EK. Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. http://www.alexjvs.com/?mno=17323 [Access: November 27, 2020]. doi:10.5455/ajvs.17323


AMA (American Medical Association) Style

Saad HM, Oda SS, Sedeek EK. Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. AJVS. 2020; 67(1): 92-98. doi:10.5455/ajvs.17323



Vancouver/ICMJE Style

Saad HM, Oda SS, Sedeek EK. Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. AJVS. (2020), [cited November 27, 2020]; 67(1): 92-98. doi:10.5455/ajvs.17323



Harvard Style

Saad, H. M., Oda, . S. S. & Sedeek, . E. K. (2020) Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. AJVS, 67 (1), 92-98. doi:10.5455/ajvs.17323



Turabian Style

Saad, Hebatallah M., Samah S. Oda, and Eman K. Sedeek. 2020. Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. Alexandria Journal of Veterinary Sciences, 67 (1), 92-98. doi:10.5455/ajvs.17323



Chicago Style

Saad, Hebatallah M., Samah S. Oda, and Eman K. Sedeek. "Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats." Alexandria Journal of Veterinary Sciences 67 (2020), 92-98. doi:10.5455/ajvs.17323



MLA (The Modern Language Association) Style

Saad, Hebatallah M., Samah S. Oda, and Eman K. Sedeek. "Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats." Alexandria Journal of Veterinary Sciences 67.1 (2020), 92-98. Print. doi:10.5455/ajvs.17323



APA (American Psychological Association) Style

Saad, H. M., Oda, . S. S. & Sedeek, . E. K. (2020) Protective Effect of Lactéol® Forte Against Thioacetamide-Induced Hepatic Injury in Male Albino Rats. Alexandria Journal of Veterinary Sciences, 67 (1), 92-98. doi:10.5455/ajvs.17323





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