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Original Research (Original Article) 


Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats

Mohamed M. Zeweil, Ali H. El-Far, Kadry M. Sadek, Usama E. Mahrous, Ahmed S. Ahmed.

Abstract
The effects of desert camel milk (CM) and desert camel urine (CU) on thioacetamide-induced liver cirrhosis were studied in rats. Therefore one hundred and thirty male rats were allocated into ten groups. The non-cirrhotic control animals were allocated into five groups each consisted of ten rats. The cirrhotic animals were allocated into five groups. Cirrhotic groups were received CM and CU alone or mixed for 12 weeks with an intraperitoneal (IP) thioacetamide (200 mg/kg) injection. Liver damage was assessed by estimation of tissue oxidant malondialdhyde (MDA) and total antioxidant capacity (TAC). Moreover serum levels of total proteins, albumin, globulin and A/G ratio in addition to alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP) activities besides serum bilirubin, cholesterol, triacylglycerols, creatinine and urea were determined. Treatment with CM alone or mixed with CU significantly reduced thioacetamide-induced elevation in tissue MDA as well as serum enzymes (ALT, AST, GGT and ALP), total cholesterol (TC), triacylglycerols (TAG), creatinine and urea. This study gives an evidence that the thioacetamide-induced liver cirrhosis in rats can be ameliorated by administration of CM and CU especially in a dose of 2CM: 1CU.

Key words: Hepatoprotective; Liver Cirrhosis; Thioacetamide; Desert camel milk; Desert camel urine.


 
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How to Cite this Article
Pubmed Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . AJVS. 2016; 49(2): 170-177. doi:10.5455/ajvs.207096

Web Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . http://www.alexjvs.com/?mno=230428 [Access: February 09, 2020]. doi:10.5455/ajvs.207096

AMA (American Medical Association) Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . AJVS. 2016; 49(2): 170-177. doi:10.5455/ajvs.207096


Vancouver/ICMJE Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . AJVS. (2016), [cited February 09, 2020]; 49(2): 170-177. doi:10.5455/ajvs.207096


Harvard Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed (2016) Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . AJVS, 49 (2), 170-177. doi:10.5455/ajvs.207096


Turabian Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. 2016. Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . Alexandria Journal of Veterinary Sciences, 49 (2), 170-177. doi:10.5455/ajvs.207096


Chicago Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. "Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats ." Alexandria Journal of Veterinary Sciences 49 (2016), 170-177. doi:10.5455/ajvs.207096


MLA (The Modern Language Association) Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed. "Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats ." Alexandria Journal of Veterinary Sciences 49.2 (2016), 170-177. Print. doi:10.5455/ajvs.207096


APA (American Psychological Association) Style

Mohamed M. Zeweil , Ali H. El-Far , Kadry M. Sadek , Usama E. Mahrous , Ahmed S. Ahmed (2016) Effect of Desert Camel's Milk and/or Urine on Experimentally Induced Thioacetamide Liver Cirrhosis in Rats . Alexandria Journal of Veterinary Sciences, 49 (2), 170-177. doi:10.5455/ajvs.207096




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