E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats

Abd El Salam F. EL-Sawy, Zynab kh. EL-Maddawy, Ahmed Bargal.

Abstract
The present study was conducted to study some pharmacodynamics and the possible adverse effects of Phenylbutazone in mature male rats . Haematological , biochemical and histopathological studies were carried out.
Mature male albino rats were used and divided into 3 equal groups each of 15 rats. Rats of the first group were kept as a control and intramuscularly injected with propylene glycol (2 ml ./kg b.wt.) once daily for 3 successive days . Rats of the second group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 53.3 mg./kg. b.wt. Rats of the third group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 106.6 mg/kg. b.wt .
Five rats from each control and treated groups were killed at 2 nd, 4 th and 8th week from beginning of drug administration to obtain blood, semen and some body organs for examination and evaluation .
The obtained results showed that i/ m administration of different doses of Phenylbutazone to male rats induced a variety of side effects on blood picture, biochemical and the reproductive parameters. Moreover, Phenylbutazone induced many histo-pathological alterations in the reproductive organs, liver and kidney of the treated male rats . Therefore, prolonged administration of Phenylbutazone should be avoided .

Key words: phenylbutazone, Male Rats, Liver functions ,blood picture


 
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Pubmed Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. 2018; 58(1): 120-131. doi:10.5455/ajvs.269397


Web Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. http://www.alexjvs.com/?mno=269397 [Access: October 16, 2018]. doi:10.5455/ajvs.269397


AMA (American Medical Association) Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. 2018; 58(1): 120-131. doi:10.5455/ajvs.269397



Vancouver/ICMJE Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. (2018), [cited October 16, 2018]; 58(1): 120-131. doi:10.5455/ajvs.269397



Harvard Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal (2018) Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS, 58 (1), 120-131. doi:10.5455/ajvs.269397



Turabian Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. 2018. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 120-131. doi:10.5455/ajvs.269397



Chicago Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. "Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats." Alexandria Journal of Veterinary Sciences 58 (2018), 120-131. doi:10.5455/ajvs.269397



MLA (The Modern Language Association) Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal. "Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats." Alexandria Journal of Veterinary Sciences 58.1 (2018), 120-131. Print. doi:10.5455/ajvs.269397



APA (American Psychological Association) Style

Abd El Salam F. EL-Sawy| Zynab kh. EL-Maddawy| Ahmed Bargal (2018) Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 120-131. doi:10.5455/ajvs.269397





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