E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Research (Original Article) 


Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens

Nagah Arafat, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, Rasha M. Saleh.

Abstract
The present study was undertaken to evaluate the potential nephro- and hepato- protective as well as antioxidant effects of Moringa oleifera leaves extract (1% and 0.5%) against gentamicin induced toxicity (55 mg/kg body weight) in chickens. Growth performance, clinical signs, gross lesions, and mortality rates were evaluated at 1st, 2nd and 3rd weeks post gentamicin injection. Immune response, serum biochemical indices, antioxidant parameters and histopathology of liver and kidney were evaluated at 1st and 3rd weeks post gentamicin injection. Alterations in growth performance, immune response and oxidative stress markers in the liver and the kidney with increased mortality were observed in gentamicin treated group. Moreover, gentamicin exhibited a significant increase in serum hepatic and renal injury biomarkers as well as microscopic pathological lesions. However, Moringa oleifera leaves extract when given along with gentamicin, reversed the severity of gentamicin drawbacks, nephrotoxicity and hepatotoxicity by normalized the altered serum levels of liver and kidney biomarkers. Moreover, it reduced tissue nitric oxide and oxidative stress. In conclusion, the present study suggest that, Moringa oleifera leaves extract might play an important role in reducing oxidative stress, kidney and liver damage induced by gentamicin in chickens.

Key words: Antioxidant, chickens, gentamicin; Moringa oleifera, hepatotoxicity, nephrotoxicity


 
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Pubmed Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. 2018; 58(1): 173-185. doi:10.5455/ajvs.299702


Web Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. http://www.alexjvs.com/?mno=299702 [Access: December 10, 2018]. doi:10.5455/ajvs.299702


AMA (American Medical Association) Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. 2018; 58(1): 173-185. doi:10.5455/ajvs.299702



Vancouver/ICMJE Style

Arafat N, Awadin WF, El-Shafei RA, Farag VM, Saleh RM. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS. (2018), [cited December 10, 2018]; 58(1): 173-185. doi:10.5455/ajvs.299702



Harvard Style

Arafat, N., Awadin, . W. F., El-Shafei, . R. A., Farag, . V. M. & Saleh, . R. M. (2018) Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. AJVS, 58 (1), 173-185. doi:10.5455/ajvs.299702



Turabian Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. 2018. Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. Alexandria Journal of Veterinary Sciences, 58 (1), 173-185. doi:10.5455/ajvs.299702



Chicago Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. "Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens." Alexandria Journal of Veterinary Sciences 58 (2018), 173-185. doi:10.5455/ajvs.299702



MLA (The Modern Language Association) Style

Arafat, Nagah, Walaa F. Awadin, Reham A. El-Shafei, Verginia M.E. Farag, and Rasha M. Saleh. "Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens." Alexandria Journal of Veterinary Sciences 58.1 (2018), 173-185. Print. doi:10.5455/ajvs.299702



APA (American Psychological Association) Style

Arafat, N., Awadin, . W. F., El-Shafei, . R. A., Farag, . V. M. & Saleh, . R. M. (2018) Protective Role of Moringa oleifera Leaves Extract Against Gentamicin-induced Nephro- and Hepato- Toxicity in Chickens. Alexandria Journal of Veterinary Sciences, 58 (1), 173-185. doi:10.5455/ajvs.299702





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