Abstract
Abstract
Objective
The objective of the this study is to investigate the protective effect of curcumin on paracetamol induced hepatotoxicity in rats through determination of, serum protein concentration, ammonia, bilirubin, liver enzymes activities, liver lipid peroxidation and antioxidants. The study was carried on 70 male rats weighing 140± 10 divided into equal 7 groups as following: GI: control, GII: control corn, GIII: curcumin (200mg/kgb.wt/gavage), GIV: curcumin (400mg/kgb.wt/gavage), GV: paracetamol (500mg/kgb.wt/gavage), GVI: Curcumin (200mg/kgb.wt/gavage) + paracetamol (500mg/kgb.wt/gavage) and GVII: curcumin (400mg/kgb.wt/ gavage)+ paracetamol (500mg/kgb.wt/ gavage). After 30 days, blood was collected for biochemical examination.
Results:
Paracetamol at dose (500 mg/kg b.wt) caused marked liver damage as there was pronounced increase in bilirubin, ammonia and MDA levels along with marked elevation in liver enzyme activities while levels of serum proteins, GSH and Catalase activity markedly decreased. Interestingly, curcumin was able to ameliorate hepatic deterioration caused by paracetamol via restoring depleted glutathione, rebalanced antioxidants and improved damage as curcumin (200 mg/ kg b.wt) successfully decreased degree of hepatic vacuolation with best improvent via curcumin (400 mg/ kg b.wt).
Conclusion:
Curcumin showed protective effect on paracetamol induced hepatotoxicity as it successfully improved the altered hepatic parameters and through its powerful antioxidant properties.

Key words: Keywords: Hepatotoxicity, paracetamol, curcumin, antioxidant.