E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs

Emmanuella A.O. Sogebi, Adeniran Adetunji, Oluwaseun S. Olatunji.

Abstract
This study evaluated the comparative effects of Acepromazine-Butorphanol and Acepromazine-Buprenorphine premedicants in Propofol-Isoflurane anaesthesized Nigerian indigenous dogs. Using a prospective cross-over blinded clinical study, six adult Nigerian indigenous dogs were randomly selected for two trials with one week ‘wash out’ period between each trial. Trial I and Trial II were premedicated with Acepromazine+Butorphanol (0.04mg/kg IM + 0.3mg/kg IM) and Acepromazine+Buprenorphine (0.04mg/kg IM + 0.03mg/kg IM) respectively. Anaesthesia was induced in the two trials with Propofol (4mg/kg IV) and maintained with Isoflurane 2% in 2 liters of Oxygen. Cardiopulmonary parameters were recorded at 15minute intervals for 180 minutes. Anaesthetic indices, analgesia and side effects of the drugs were also observed. The study showed no significant alterations (p>0.05) in the anaesthetic indices of dogs in the two protocols. There were significant increases in heart and pulse rates at 45min post premedication in Acepromazine-Buprenorphine compared to Acepromazine-Butophanol. Hypotension was observed in Acepromazine-Buprenorphine premedicated dogs with no-significant decrease in MAP from 60 minutes post premedication. The degree of analgesia achieved with Acepromazine-Butorphanol was moderate while that of Acepromazine-Buprenorphine trial was mild. It was concluded that, either Butorphanol or Buprenorphine can be used in combination with Acepromazine for premedication in Nigerian indigenous dogs. However, Acepromazine-Butorphanol combination appears to be a better choice of neuroleptanalgesic premedicant in dogs due to its anaesthetic advantage.

Key words: Isoflurane, Neurolept-analgesic, Nigerian breed of dogs, Propofol


 
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How to Cite this Article
Pubmed Style

Sogebi EA, Adetunji A, Olatunji OS. Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. AJVS. 2020; 65(1): 96-101. doi:10.5455/ajvs.77317


Web Style

Sogebi EA, Adetunji A, Olatunji OS. Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. https://www.alexjvs.com/?mno=77317 [Access: December 05, 2023]. doi:10.5455/ajvs.77317


AMA (American Medical Association) Style

Sogebi EA, Adetunji A, Olatunji OS. Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. AJVS. 2020; 65(1): 96-101. doi:10.5455/ajvs.77317



Vancouver/ICMJE Style

Sogebi EA, Adetunji A, Olatunji OS. Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. AJVS. (2020), [cited December 05, 2023]; 65(1): 96-101. doi:10.5455/ajvs.77317



Harvard Style

Sogebi, E. A., Adetunji, . A. & Olatunji, . O. S. (2020) Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. AJVS, 65 (1), 96-101. doi:10.5455/ajvs.77317



Turabian Style

Sogebi, Emmanuella A.O., Adeniran Adetunji, and Oluwaseun S. Olatunji. 2020. Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. Alexandria Journal of Veterinary Sciences, 65 (1), 96-101. doi:10.5455/ajvs.77317



Chicago Style

Sogebi, Emmanuella A.O., Adeniran Adetunji, and Oluwaseun S. Olatunji. "Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs." Alexandria Journal of Veterinary Sciences 65 (2020), 96-101. doi:10.5455/ajvs.77317



MLA (The Modern Language Association) Style

Sogebi, Emmanuella A.O., Adeniran Adetunji, and Oluwaseun S. Olatunji. "Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs." Alexandria Journal of Veterinary Sciences 65.1 (2020), 96-101. Print. doi:10.5455/ajvs.77317



APA (American Psychological Association) Style

Sogebi, E. A., Adetunji, . A. & Olatunji, . O. S. (2020) Comparison of Two Neurolept-Analgesics Agents on Propofol-Isoflurane Anaesthesized Nigerian Indigenous Dogs. Alexandria Journal of Veterinary Sciences, 65 (1), 96-101. doi:10.5455/ajvs.77317





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