E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem.

Abstract
Hyrperlipidemia refers to a metabolic disorder characterized by alterations in serum lipid and lipoprotein patterns as LDL-c , HDL-c and VLDL-c and is also identified as dyslipidemia which is associated with insulin resistance (T2DMS). Berberine is a plant alkaloid with a long history of medicinal uses in both traditional and Chinese medicine . Our study was carried out on 40 male albino rats. Hyperlipidemia was induced by feeding rats high fat diet for 8 weeks after which insulin resistance was developed as aconsequance to hyperlipidemia . Berberine chloride was after induction of hyperlipidemia for two weeks orally administration by stomach tube. Our result showed that serum lipid profile (TAG , TC , LDL-c) increased while HDL-c level was decrease moreover blood glucose level , insulin level , fructosamine level ,HbA1c level and HOMA-IR level increased at end of 8 weeks after development of hyperlipidemia . Addition of berberine chloride showed protective effect as decreased serum triglycerides , total cholesterol and LDL-c levels and increased HDL-c level more over it reduced insulin , glucose , fructosamine ,HbA1c and HOMA-IR levels.

Key words: Berberine , insulin resistance , hyperlipidemia


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Fayrouz M. Nagy
Articles by Nabil M. Taha
Articles by Abd El Wahab A. Mandour
Articles by Mohamed A. Lebda
Articles by Aml S. Hashem
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. AJVS. 2016; 51(2): 142-147. doi:10.5455/ajvs.240399


Web Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. https://www.alexjvs.com/?mno=240399 [Access: December 07, 2023]. doi:10.5455/ajvs.240399


AMA (American Medical Association) Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. AJVS. 2016; 51(2): 142-147. doi:10.5455/ajvs.240399



Vancouver/ICMJE Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. AJVS. (2016), [cited December 07, 2023]; 51(2): 142-147. doi:10.5455/ajvs.240399



Harvard Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem (2016) The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. AJVS, 51 (2), 142-147. doi:10.5455/ajvs.240399



Turabian Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. 2016. The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. Alexandria Journal of Veterinary Sciences, 51 (2), 142-147. doi:10.5455/ajvs.240399



Chicago Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. "The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet." Alexandria Journal of Veterinary Sciences 51 (2016), 142-147. doi:10.5455/ajvs.240399



MLA (The Modern Language Association) Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem. "The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet." Alexandria Journal of Veterinary Sciences 51.2 (2016), 142-147. Print. doi:10.5455/ajvs.240399



APA (American Psychological Association) Style

Fayrouz M. Nagy, Nabil M. Taha, Abd El Wahab A. Mandour, Mohamed A. Lebda, Aml S. Hashem (2016) The Biochemical Effects of Berberine on Hyperlipidemia and Insulin Resistance in Rats Fed High Fat Diet. Alexandria Journal of Veterinary Sciences, 51 (2), 142-147. doi:10.5455/ajvs.240399





Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

  • Most Cited Articles
    Most Cited Articles