E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats

Abd El Salam F. EL-Sawy, Zynab kh. EL-Maddawy, Ahmed Bargal.

Abstract
The present study was conducted to study some pharmacodynamics and the possible adverse effects of Phenylbutazone in mature male rats . Haematological , biochemical and histopathological studies were carried out.
Mature male albino rats were used and divided into 3 equal groups each of 15 rats. Rats of the first group were kept as a control and intramuscularly injected with propylene glycol (2 ml ./kg b.wt.) once daily for 3 successive days . Rats of the second group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 53.3 mg./kg. b.wt. Rats of the third group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 106.6 mg/kg. b.wt .
Five rats from each control and treated groups were killed at 2 nd, 4 th and 8th week from beginning of drug administration to obtain blood, semen and some body organs for examination and evaluation .
The obtained results showed that i/ m administration of different doses of Phenylbutazone to male rats induced a variety of side effects on blood picture, biochemical and the reproductive parameters. Moreover, Phenylbutazone induced many histo-pathological alterations in the reproductive organs, liver and kidney of the treated male rats . Therefore, prolonged administration of Phenylbutazone should be avoided .

Key words: phenylbutazone, Male Rats, Liver functions ,blood picture


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Abd El Salam F. EL-Sawy
Articles by Zynab kh. EL-Maddawy
Articles by Ahmed Bargal
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

EL-Sawy AESF, EL-Maddawy Zk, Bargal A. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. 2018; 58(1): 120-131. doi:10.5455/ajvs.269397


Web Style

EL-Sawy AESF, EL-Maddawy Zk, Bargal A. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. https://www.alexjvs.com/?mno=269397 [Access: December 06, 2023]. doi:10.5455/ajvs.269397


AMA (American Medical Association) Style

EL-Sawy AESF, EL-Maddawy Zk, Bargal A. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. 2018; 58(1): 120-131. doi:10.5455/ajvs.269397



Vancouver/ICMJE Style

EL-Sawy AESF, EL-Maddawy Zk, Bargal A. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS. (2018), [cited December 06, 2023]; 58(1): 120-131. doi:10.5455/ajvs.269397



Harvard Style

EL-Sawy, A. E. S. F., EL-Maddawy, . Z. k. & Bargal, . A. (2018) Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. AJVS, 58 (1), 120-131. doi:10.5455/ajvs.269397



Turabian Style

EL-Sawy, Abd El Salam F., Zynab kh. EL-Maddawy, and Ahmed Bargal. 2018. Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 120-131. doi:10.5455/ajvs.269397



Chicago Style

EL-Sawy, Abd El Salam F., Zynab kh. EL-Maddawy, and Ahmed Bargal. "Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats." Alexandria Journal of Veterinary Sciences 58 (2018), 120-131. doi:10.5455/ajvs.269397



MLA (The Modern Language Association) Style

EL-Sawy, Abd El Salam F., Zynab kh. EL-Maddawy, and Ahmed Bargal. "Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats." Alexandria Journal of Veterinary Sciences 58.1 (2018), 120-131. Print. doi:10.5455/ajvs.269397



APA (American Psychological Association) Style

EL-Sawy, A. E. S. F., EL-Maddawy, . Z. k. & Bargal, . A. (2018) Effect of Phenylbutazone on some Hematological profiles, Liver, Kidney and Reproductive organs in Male Rats. Alexandria Journal of Veterinary Sciences, 58 (1), 120-131. doi:10.5455/ajvs.269397





Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

  • Most Cited Articles
    Most Cited Articles