E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats

Ahmed A.M. Anwar, Hesham Z. Ibrahim, Sabah G. El –Banna.

Abstract
Mancozeb manganese ethylenebis dithiocarbamate polymeric complex – with zinc salts is a very important protective non-systemicfungicide, classified as an ethylenebisdithiocarbamate fungicide. It is used to control fungal diseases for a wide variety of crops because its broad-spectrum fungicidal effects and high compatibility with agrochemicals. The objective of this study was to investigate the effects of the fungicide mancozeb at different doses on some biochemical parameters, reproductive performance and histological changes in testes and thyroid gland. The low dose equal 1/7 of LD50 manc-d1 and high dose equal 1/3.5 of LD50 manc-d1. Doses of mancozeb (manc-d1 and manc-d2) adjusted according to rat's body weights. The results showed that mancozeb significantly (P<0.05) decreased plasma testosterone level, sperm count, viability, motility, and significantly (P<0.05) increased abnormal sperms, altered acrosome and abnormal DNA. Treatment of rats with manc-d1 and manc-d2 significantly (P<0.05) decreased T3. Also, T4 significantly (P<0.05) decreased in the group treated with manc-d2. Treatment of rats with manc-d1 and manc-d2 significantly (P<0.05) increased TSH. Furthermore, the histological investigation revealed that exposure to mancozeb reduced number of mature spermatozoa, necrosis and basal vacuoles observed in some tubules. On the other hand, mancozeb reduce colloid in most follicles resulting in desquamation of the follicular epithelium into the lumen of the thyroid follicles. In conclusion, despite mancozeb exhibit low acute toxicity, it has been shown to cause detrimental effects on reproduction, thyroid gland and its secretion. For this reason, it should be necessary to be careful when using mancozeb in agricultural areas and should take precautions.

Key words: Mancozeb, rats, thyroid glands, testes, histology, fungicidal -pesticide and Reproductive bioindicies


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ahmed A.M. Anwar
Articles by Hesham Z. Ibrahim
Articles by Sabah G. El –Banna
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. 2023; 77(1): 72-78. doi:10.5455/ajvs.117335


Web Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. https://www.alexjvs.com/?mno=117335 [Access: April 29, 2023]. doi:10.5455/ajvs.117335


AMA (American Medical Association) Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. 2023; 77(1): 72-78. doi:10.5455/ajvs.117335



Vancouver/ICMJE Style

Anwar AA, Ibrahim HZ, -Banna SGE. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS. (2023), [cited April 29, 2023]; 77(1): 72-78. doi:10.5455/ajvs.117335



Harvard Style

Anwar, A. A., Ibrahim, . H. Z. & -Banna, . S. G. E. (2023) Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. AJVS, 77 (1), 72-78. doi:10.5455/ajvs.117335



Turabian Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. 2023. Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. Alexandria Journal of Veterinary Sciences, 77 (1), 72-78. doi:10.5455/ajvs.117335



Chicago Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. "Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats." Alexandria Journal of Veterinary Sciences 77 (2023), 72-78. doi:10.5455/ajvs.117335



MLA (The Modern Language Association) Style

Anwar, Ahmed A.M., Hesham Z. Ibrahim, and Sabah G. El -Banna. "Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats." Alexandria Journal of Veterinary Sciences 77.1 (2023), 72-78. Print. doi:10.5455/ajvs.117335



APA (American Psychological Association) Style

Anwar, A. A., Ibrahim, . H. Z. & -Banna, . S. G. E. (2023) Biochemical Changes of Mancozeb-Induced Alternations in Testes and Thyroid gland of Male Albino Rats. Alexandria Journal of Veterinary Sciences, 77 (1), 72-78. doi:10.5455/ajvs.117335





Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Most Downloaded
  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract & References » doi: 10.5455/ajvs.47290

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Most Cited Articles
  • Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken
    Mohamed El-Katcha, Mosad A. Soltan, M. El-badry
    AJVS. 2017; 55(2): 129-145
    » Abstract » doi: 10.5455/ajvs.266925
    Cited : 16 times [Click to see citing articles]

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 12 times [Click to see citing articles]

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232
    Cited : 9 times [Click to see citing articles]

  • Molecular Characterization, Antimicrobial Susceptibility and Salt Tolerance of Aeromonas hydrophila from Fresh, Brackish and Marine fishes
    Basma Dahdouh, Ola Basha, Samy Khalil, Mahmoud Tanekhy
    AJVS. 2016; 48(2): 46-53
    » Abstract & References » doi: 10.5455/ajvs.208107
    Cited : 9 times [Click to see citing articles]

  • Detection of Molecular Characterization of Salmonella enterica isolated from Chicken Meat and Its Products by Using Multiplex PCR
    Heba S. Amin and Abd El-Rahman A. Abd El-Rahman
    AJVS. 2015; 46(1): 155-160
    » Abstract & References » doi: 10.5455/ajvs.196302
    Cited : 7 times [Click to see citing articles]