E-ISSN 2536-9520 | ISSN 1110-2047
 
2023, Vol: 79, Issue: 1
79 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage

Heba M. Shaaban, El- Sayed E. Mehana, Samah S. Oda, Hossam G. Tohamy, Dina R. Gad El-Karim.

Abstract
This study was carried outto investigatethe ameliorative effect of both of Dandelion and Ginko.biloba extract on liver toxicities induced by thioacetamide (TAA) in male albino rats.Sixty male albino rats were divided into sixgroups (10 rats pereach).Group 1 (Negative control): which received 1 ml of saline orally and 1ml of saline intra-peritoneal (I/P),Group 2: received TAA for induction of hepatic injuryGroup 3:received TAA+ ginkgo biloba extract (50 mg/ b.wt.),Group 4: received TAA+ ginkgo biloba extract (100 mg/ kg b.wt.).Group 5: which received TAA + dandelion extract (250 mg/ kg b.wt).Group 6: which received TAA+ dandelion extract (500 mg/ kg b.wt.).TAA was administrated by I/P route at dose level of 250mg/kg b.wt , extracts were administrated orally, they were administrated 3 times/week for 4 weeks. The obtained results revealed that intoxication with TAAshowed a significant elevation in serum liver enzymes activity, total bilirubinplussignificant decrease in serum levels of total proteins andalbumin, significant increase in total cholesterol and triglycerides.At the same time ,intoxication with TAA exhibited severe oxidative damged stress ,represented by a significant increase in hepatic level of malondialdehyde (MDA)as well asa significant decrease in reduced glutathione (GSH).The characteristic pathological changes were represented by ,(TAA),severe degenerative andnecrotic alterationsin the hepatocytes. The treatment with G.biloba and D- in different treateddosesattenuatedTAA-induced,serum biochemical alterations, oxidative stressand histopathological changes in liver.

Key words: Thioacetamid, Ginkgobiloba, Dandelion, Rats, Hepatic toxicity, Histopathology, Oxidative stress


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Heba M. Shaaban
Articles by El- Sayed E. Mehana
Articles by Samah S. Oda
Articles by Hossam G. Tohamy
Articles by Dina R. Gad El-Karim
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Shaaban HM, Mehana ESE, Oda SS, Tohamy HG, El-Karim DRG. Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. AJVS. 2023; 76(2): 90-94. doi:10.5455/ajvs.124405

Web Style

Shaaban HM, Mehana ESE, Oda SS, Tohamy HG, El-Karim DRG. Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. https://www.alexjvs.com/?mno=124405 [Access: December 06, 2023]. doi:10.5455/ajvs.124405

AMA (American Medical Association) Style

Shaaban HM, Mehana ESE, Oda SS, Tohamy HG, El-Karim DRG. Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. AJVS. 2023; 76(2): 90-94. doi:10.5455/ajvs.124405


Vancouver/ICMJE Style

Shaaban HM, Mehana ESE, Oda SS, Tohamy HG, El-Karim DRG. Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. AJVS. (2023), [cited December 06, 2023]; 76(2): 90-94. doi:10.5455/ajvs.124405


Harvard Style

Shaaban, H. M., Mehana, . E. S. E., Oda, . S. S., Tohamy, . H. G. & El-Karim, . D. R. G. (2023) Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. AJVS, 76 (2), 90-94. doi:10.5455/ajvs.124405


Turabian Style

Shaaban, Heba M., El- Sayed E. Mehana, Samah S. Oda, Hossam G. Tohamy, and Dina R. Gad El-Karim. 2023. Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. Alexandria Journal of Veterinary Sciences, 76 (2), 90-94. doi:10.5455/ajvs.124405


Chicago Style

Shaaban, Heba M., El- Sayed E. Mehana, Samah S. Oda, Hossam G. Tohamy, and Dina R. Gad El-Karim. "Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage." Alexandria Journal of Veterinary Sciences 76 (2023), 90-94. doi:10.5455/ajvs.124405


MLA (The Modern Language Association) Style

Shaaban, Heba M., El- Sayed E. Mehana, Samah S. Oda, Hossam G. Tohamy, and Dina R. Gad El-Karim. "Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage." Alexandria Journal of Veterinary Sciences 76.2 (2023), 90-94. Print. doi:10.5455/ajvs.124405


APA (American Psychological Association) Style

Shaaban, H. M., Mehana, . E. S. E., Oda, . S. S., Tohamy, . H. G. & El-Karim, . D. R. G. (2023) Clinico-pathological Evaluation of Hepatoprotective Effect of Dandelion and Ginkgo-biloba Extract against Thioacetamide Induced Liver Damage. Alexandria Journal of Veterinary Sciences, 76 (2), 90-94. doi:10.5455/ajvs.124405




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine, Alexandria University
    Edfina, Behaira, Egypt.
    PO.Box: 22758
    Telefax: +20 45 2963526
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use