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2024, Vol: 80, Issue: 1
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Original Article 


Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats

Monday M. Onakpa, Maxwell O. Egua, Florence C. Nwinyi, Motunrayo G. Akande, Hudu G. Mikail, Julius O. Ode, David D. Akumka, Mohammed Adamu.

Abstract
Feretia apodanthera is a shrub with twisting branches commonly used in folklore medicine to manage erectile dysfunction and to treat stomach upset. In this study, the leaf extract of Feretia apodanthera was extracted using 80% methanol. Phytochemical analysis and in vitro antioxidant test using the Ferric Reducing/Antioxidant Power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. Acute toxicity study of the extract was carried out using the Lorke’s method. The hypoglycaemic studies were done in normal and glucose-challenged rats. The doses of the extract of Feretia apodanthera administered the rats through the oral route were 100, 200, and 400 mg/kg. The outcomes were compared with glibenclamide (0.2 mg/kg per os) and those of the normal saline. Phytochemical composition of the extract of Feretia apodanthera included saponins, terpenes, tannins, steroids, and carbohydrates. This result shows that extract of Feretia apodanthera has antioxidant and hypoglycemic properties. Further studies aimed at isolating the active hypoglycemic compound of the leaf extract of Feretia apodanthera are recommended.

Key words: Feretia apodanthera; rats; antioxidant


 
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How to Cite this Article
Pubmed Style

Onakpa MM, Egua MO, Nwinyi FC, Akande MG, Mikail HG, Ode JO, Akumka DD, Adamu M. Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. AJVS. 2023; 79(1): 51-59. doi:10.5455/ajvs.130018

Web Style

Onakpa MM, Egua MO, Nwinyi FC, Akande MG, Mikail HG, Ode JO, Akumka DD, Adamu M. Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. https://www.alexjvs.com/?mno=130018 [Access: December 03, 2023]. doi:10.5455/ajvs.130018

AMA (American Medical Association) Style

Onakpa MM, Egua MO, Nwinyi FC, Akande MG, Mikail HG, Ode JO, Akumka DD, Adamu M. Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. AJVS. 2023; 79(1): 51-59. doi:10.5455/ajvs.130018


Vancouver/ICMJE Style

Onakpa MM, Egua MO, Nwinyi FC, Akande MG, Mikail HG, Ode JO, Akumka DD, Adamu M. Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. AJVS. (2023), [cited December 03, 2023]; 79(1): 51-59. doi:10.5455/ajvs.130018


Harvard Style

Onakpa, M. M., Egua, . M. O., Nwinyi, . F. C., Akande, . M. G., Mikail, . H. G., Ode, . J. O., Akumka, . D. D. & Adamu, . M. (2023) Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. AJVS, 79 (1), 51-59. doi:10.5455/ajvs.130018


Turabian Style

Onakpa, Monday M., Maxwell O. Egua, Florence C. Nwinyi, Motunrayo G. Akande, Hudu G. Mikail, Julius O. Ode, David D. Akumka, and Mohammed Adamu. 2023. Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. Alexandria Journal of Veterinary Sciences, 79 (1), 51-59. doi:10.5455/ajvs.130018


Chicago Style

Onakpa, Monday M., Maxwell O. Egua, Florence C. Nwinyi, Motunrayo G. Akande, Hudu G. Mikail, Julius O. Ode, David D. Akumka, and Mohammed Adamu. "Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats." Alexandria Journal of Veterinary Sciences 79 (2023), 51-59. doi:10.5455/ajvs.130018


MLA (The Modern Language Association) Style

Onakpa, Monday M., Maxwell O. Egua, Florence C. Nwinyi, Motunrayo G. Akande, Hudu G. Mikail, Julius O. Ode, David D. Akumka, and Mohammed Adamu. "Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats." Alexandria Journal of Veterinary Sciences 79.1 (2023), 51-59. Print. doi:10.5455/ajvs.130018


APA (American Psychological Association) Style

Onakpa, M. M., Egua, . M. O., Nwinyi, . F. C., Akande, . M. G., Mikail, . H. G., Ode, . J. O., Akumka, . D. D. & Adamu, . M. (2023) Hypoglycaemic and Antioxidant Properties of Feretia Apodanthera Methanolic Leaf Extract in Wistar Rats. Alexandria Journal of Veterinary Sciences, 79 (1), 51-59. doi:10.5455/ajvs.130018




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