Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1

Elshaimaa Ismael; Mohamed M. Hamod; Abd El-Rahman M. Gamal; Mohga F. Badawy; Manal M. Zaki; Shimaa A.E Nasr; Hamed A. Samaha; Hassan. M. Elagrab; Sherif T. Moubarak; Osama K. Zahran

doi:10.5455/ajvs.162985

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Original Article
Online Published: 04 Aug 2014

AJVS. 2014; 42(1): 64-73

doi: 10.5455/ajvs.162985

Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1

Elshaimaa Ismael, Mohamed M. Hamod, Abd El-rahman M. Gamal, Mohga F. Badawy, Manal M. Zaki, Shimaa A.e Nasr, Hamed A. Samaha, Hassan. M. Elagrab, Sherif T. Moubarak, Osama K. Zahran.

Abstract
Two HPAI H5N1 viruses were isolated from vaccinated layer and broiler commercial poultry farms in Egypt at years 2011 and 2013; respectively. By phylogenetic analysis, the viruses fall into two genetically diverse clades: (i) A/chicken/Egypt/VRLCU67/2011 classified as a variant virus, clade 2.2.1.1; and (ii) A/chicken/Egypt/13VIR3729-4/2013 classified as a classic virus, clade 2.2.1.
Cross HI-test confirmed that the reaction between the two viruses is weak; furthermore, it showed the antigenic diversity between viruses belong to different clades and antigenic groups.
Antigenic relatedness was calculated between six AI antigens and their antisera representing the different clades and antigenic groups circulated in Egyptian field; including the A/chicken/Egypt/VRLCU67/2011 strain which showed very low R-values with the other viruses groups; ranging from 17 % to zero. Results demonstrated the genetic and antigenic diversity of the variant viruses and how can the vaccine seed be a weak point in the vaccination program that could be broken by the drifted viruses antigenically distant from the vaccine strain.

Key words: AI H5N1 - antigenic relatedness - vaccine - Haemagglutinination ihibition test

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Pubmed Style

Ismael E, Hamod MM, Gamal AEM, Badawy MF, Zaki MM, Nasr SA, Samaha HA, Elagrab HM, Moubarak ST, Zahran OK. Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. AJVS. 2014; 42(1): 64-73. doi:10.5455/ajvs.162985

Web Style

Ismael E, Hamod MM, Gamal AEM, Badawy MF, Zaki MM, Nasr SA, Samaha HA, Elagrab HM, Moubarak ST, Zahran OK. Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. https://www.alexjvs.com/?mno=162985 [Access: May 04, 2025]. doi:10.5455/ajvs.162985

AMA (American Medical Association) Style

Ismael E, Hamod MM, Gamal AEM, Badawy MF, Zaki MM, Nasr SA, Samaha HA, Elagrab HM, Moubarak ST, Zahran OK. Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. AJVS. 2014; 42(1): 64-73. doi:10.5455/ajvs.162985

Vancouver/ICMJE Style

Ismael E, Hamod MM, Gamal AEM, Badawy MF, Zaki MM, Nasr SA, Samaha HA, Elagrab HM, Moubarak ST, Zahran OK. Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. AJVS. (2014), [cited May 04, 2025]; 42(1): 64-73. doi:10.5455/ajvs.162985

Harvard Style

Ismael, E., Hamod, . M. M., Gamal, . A. E. M., Badawy, . M. F., Zaki, . M. M., Nasr, . S. A., Samaha, . H. A., Elagrab, . H. M., Moubarak, . S. T. & Zahran, . O. K. (2014) Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. AJVS, 42 (1), 64-73. doi:10.5455/ajvs.162985

Turabian Style

Ismael, Elshaimaa, Mohamed M. Hamod, Abd El-rahman M. Gamal, Mohga F. Badawy, Manal M. Zaki, Shimaa A.e Nasr, Hamed A. Samaha, Hassan. M. Elagrab, Sherif T. Moubarak, and Osama K. Zahran. 2014. Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1. Alexandria Journal of Veterinary Sciences, 42 (1), 64-73. doi:10.5455/ajvs.162985

Chicago Style

Ismael, Elshaimaa, Mohamed M. Hamod, Abd El-rahman M. Gamal, Mohga F. Badawy, Manal M. Zaki, Shimaa A.e Nasr, Hamed A. Samaha, Hassan. M. Elagrab, Sherif T. Moubarak, and Osama K. Zahran. "Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1." Alexandria Journal of Veterinary Sciences 42 (2014), 64-73. doi:10.5455/ajvs.162985

MLA (The Modern Language Association) Style

Ismael, Elshaimaa, Mohamed M. Hamod, Abd El-rahman M. Gamal, Mohga F. Badawy, Manal M. Zaki, Shimaa A.e Nasr, Hamed A. Samaha, Hassan. M. Elagrab, Sherif T. Moubarak, and Osama K. Zahran. "Epidemiological Study on the Impact of Vaccination Programs on Antigenic Relatedness, Genetic Characterization of Highly pathogenic Avian Influenza H5N1." Alexandria Journal of Veterinary Sciences 42.1 (2014), 64-73. Print. doi:10.5455/ajvs.162985

APA (American Psychological Association) Style

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