E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga.

Abstract
The present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6th weeks and the 12th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.

Key words: aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degeneration.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Heba-allah M. Saad
Articles by Mostafa M. Hassieb
Articles by Samah S. Oda
Articles by Hossam G. Tohamy
Articles by Asmaa F. Khafaga
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783


Web Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. https://www.alexjvs.com/?mno=264783 [Access: December 05, 2023]. doi:10.5455/ajvs.264783


AMA (American Medical Association) Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783



Vancouver/ICMJE Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. (2018), [cited December 05, 2023]; 56(1): 102-109. doi:10.5455/ajvs.264783



Harvard Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga (2018) Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS, 56 (1), 102-109. doi:10.5455/ajvs.264783



Turabian Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. 2018. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. Alexandria Journal of Veterinary Sciences, 56 (1), 102-109. doi:10.5455/ajvs.264783



Chicago Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. "Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits." Alexandria Journal of Veterinary Sciences 56 (2018), 102-109. doi:10.5455/ajvs.264783



MLA (The Modern Language Association) Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga. "Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits." Alexandria Journal of Veterinary Sciences 56.1 (2018), 102-109. Print. doi:10.5455/ajvs.264783



APA (American Psychological Association) Style

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga (2018) Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. Alexandria Journal of Veterinary Sciences, 56 (1), 102-109. doi:10.5455/ajvs.264783





Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

  • Most Cited Articles
    Most Cited Articles