Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats

Asmaa M. Khamis; Samah S. Oda; Asmaa F. Khafaga; Mohamed A. Hashem

doi:10.5455/ajvs.267052

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Original Article

AJVS. 2017; 55(2): 77-82

doi: 10.5455/ajvs.267052

Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem.

Abstract
The toxicity of hydroxyurea (HU), a treatment for specific neoplasms, sickle-cell disease, polycythemia vera and thrombocytosis was assessed in rats. Forty rats were divided equally into four groups. The first group was kept as control and received only purified water, the second group (HU250) orally administered hydroxyurea 250 mg/kg b.wt/day, the third group (HU500) administered hydroxyurea 500 mg/kg b.wt/day and the fourth group (HU750) administered hydroxyurea 750 mg/kg b.wt/day. The treatment was continued for 20 days. The evaluated parameters were assessed after 10 and 20 days of the experiment. Results revealed decrease in body weight in all treated groups. In addition, decreased circulating leukocytes, erythrocytes and platelets with decreased bone marrow cellularity were evident in all treated groups with different degree of severity. Moreover, aplastic anemia associated with marked severe hypocellularity of bone marrow was detected in HU500 and HU750 groups on the second period of the experiment. It could be concluded that hydroxyurea administration induced hematopoietic and bone marrow toxicity in rats.

Key words: hydroxyurea, bone marrow, aplastic anemia, hematology.

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Pubmed Style

Khamis AM, Oda SS, Khafaga AF, Hashem MA. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. 2017; 55(2): 77-82. doi:10.5455/ajvs.267052

Web Style

Khamis AM, Oda SS, Khafaga AF, Hashem MA. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. https://www.alexjvs.com/?mno=267052 [Access: May 04, 2025]. doi:10.5455/ajvs.267052

AMA (American Medical Association) Style

Khamis AM, Oda SS, Khafaga AF, Hashem MA. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. 2017; 55(2): 77-82. doi:10.5455/ajvs.267052

Vancouver/ICMJE Style

Khamis AM, Oda SS, Khafaga AF, Hashem MA. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS. (2017), [cited May 04, 2025]; 55(2): 77-82. doi:10.5455/ajvs.267052

Harvard Style

Khamis, A. M., Oda, . S. S., Khafaga, . A. F. & Hashem, . M. A. (2017) Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. AJVS, 55 (2), 77-82. doi:10.5455/ajvs.267052

Turabian Style

Khamis, Asmaa M., Samah S. Oda, Asmaa F. Khafaga, and Mohamed A. Hashem. 2017. Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 55 (2), 77-82. doi:10.5455/ajvs.267052

Chicago Style

Khamis, Asmaa M., Samah S. Oda, Asmaa F. Khafaga, and Mohamed A. Hashem. "Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 55 (2017), 77-82. doi:10.5455/ajvs.267052

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Khamis, A. M., Oda, . S. S., Khafaga, . A. F. & Hashem, . M. A. (2017) Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 55 (2), 77-82. doi:10.5455/ajvs.267052

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