E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 89
89Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article
Online Published: 16 Feb 2026
 


Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats

Abother K. Sahib, Buthaina A. Abdullah.


Abstract
This study aimed to evaluate the neuroprotective effects of the systematically used ginger and the mechanism of action on alloxan invoked diabetic neuropathy with specific focus on management of painful diabetic neuropathy (PDN). Thirty adult male rats (200 to 250 g) were randomly divided into six groups; control, alloxan (100 mg/kg), ginger extract, phytosome ginger, phytosome ginger with glibenclamide, and ginger extract with glibenclamide. All treatments were administered orally for one month. Histopathological examination of the sciatic nerve showed that alloxan caused intensive neuropathic injury characterized by axonal degeneracy, breaks of myelin sheath, endoneurial thickening, vascular congestion, and inflammatory cell infiltration. Ginger extract partially reduced these changes, whereas phytosome ginger showed higher bioactivity in terms of enhanced nerve fiber organization and reduced Schwann cell and inflammatory.responses.

Key words: Alloxan, Diabetes, Ginger, Glibenclamide, Phytosome, Rats


 
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Pubmed Style

Sahib AK, Abdullah BA. Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. AJVS. 2026; 89(0): 63-69. doi:10.5455/ajvs.308532

Web Style

Sahib AK, Abdullah BA. Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. https://www.alexjvs.com/?mno=308532 [Access: April 16, 2026]. doi:10.5455/ajvs.308532

AMA (American Medical Association) Style

Sahib AK, Abdullah BA. Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. AJVS. 2026; 89(0): 63-69. doi:10.5455/ajvs.308532


Vancouver/ICMJE Style

Sahib AK, Abdullah BA. Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. AJVS. (2026), [cited April 16, 2026]; 89(0): 63-69. doi:10.5455/ajvs.308532


Harvard Style

Sahib, A. K. & Abdullah, . B. A. (2026) Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. AJVS, 89 (0), 63-69. doi:10.5455/ajvs.308532


Turabian Style

Sahib, Abother K., and Buthaina A. Abdullah. 2026. Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. Alexandria Journal of Veterinary Sciences, 89 (0), 63-69. doi:10.5455/ajvs.308532


Chicago Style

Sahib, Abother K., and Buthaina A. Abdullah. "Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats." Alexandria Journal of Veterinary Sciences 89 (2026), 63-69. doi:10.5455/ajvs.308532


MLA (The Modern Language Association) Style

Sahib, Abother K., and Buthaina A. Abdullah. "Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats." Alexandria Journal of Veterinary Sciences 89.0 (2026), 63-69. Print. doi:10.5455/ajvs.308532


APA (American Psychological Association) Style

Sahib, A. K. & Abdullah, . B. A. (2026) Evaluating the Impact of Phytosome Ginger on Histological Section of Sciatic Nerve Dysfunction caused by Alloxan Induced Diabetes in Male Rats. Alexandria Journal of Veterinary Sciences, 89 (0), 63-69. doi:10.5455/ajvs.308532




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Egypt.

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