E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 90
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Original Article
Online Published: 27 Jul 2026
 


Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy

Nguyen Thi Chuc, Nguyen Minh Tri, Nguyen Thi My Phuong, Trinh Thi Hong Mo, Thai Thi Thanh Trang, Phan Nhan.


Abstract
Canine parvovirus (CPV) is a highly contagious viral disease causing severe hemorrhagic enteritis, dehydration, and high mortality in dogs, particularly in young puppies. This study aimed to evaluate the epidemiological characteristics, clinical manifestations, hematobiochemical alterations, and treatment outcomes in dogs naturally infected with CPV. Dogs younger than three months of age, free-roaming dogs, and unvaccinated dogs showed significantly higher infection rates than other groups. The most common clinical signs included depression and anorexia (100.00%), vomiting (94.25%), hemorrhagic diarrhea (89.65%), and fever (87.35%), with moderate dehydration being the most frequent dehydration degree (51.72%). Hematological analysis revealed decreased red blood cell counts, a high frequency of anemia (80.00%), variable leukocyte responses, and limited thrombocytopenia in infected dogs, whereas serum biochemical examination showed elevated AST, ALT, and BUN levels compared with normal reference values. Supportive therapy achieved a clinical recovery rate of 85.00%, based only on apparent clinical improvement. CPV infection was strongly associated with age, management conditions, and vaccination status. The disease caused marked clinical, hematological, and biochemical alterations associated with intestinal damage, dehydration, metabolic disturbance, and secondary systemic effects. Early diagnosis, appropriate fluid therapy, supportive treatment, and vaccination programs are important for improving clinical outcomes and reducing disease severity in dogs infected with CPV.

Key words: canine parvovirus, dogs, epidemiology, hematobiochemical alterations, supportive therapy, treatment outcomes.


 
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How to Cite this Article
Pubmed Style

Chuc NT, Tri NM, Phuong NTM, Mo TTH, Trang TTT, Nhan P. Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. AJVS. 2026; 90(0): 260-270. doi:10.5455/ajvs.320932

Web Style

Chuc NT, Tri NM, Phuong NTM, Mo TTH, Trang TTT, Nhan P. Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. https://www.alexjvs.com/?mno=320932 [Access: July 27, 2026]. doi:10.5455/ajvs.320932

AMA (American Medical Association) Style

Chuc NT, Tri NM, Phuong NTM, Mo TTH, Trang TTT, Nhan P. Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. AJVS. 2026; 90(0): 260-270. doi:10.5455/ajvs.320932


Vancouver/ICMJE Style

Chuc NT, Tri NM, Phuong NTM, Mo TTH, Trang TTT, Nhan P. Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. AJVS. (2026), [cited July 27, 2026]; 90(0): 260-270. doi:10.5455/ajvs.320932


Harvard Style

Chuc, N. T., Tri, . N. M., Phuong, . N. T. M., Mo, . T. T. H., Trang, . T. T. T. & Nhan, . P. (2026) Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. AJVS, 90 (0), 260-270. doi:10.5455/ajvs.320932


Turabian Style

Chuc, Nguyen Thi, Nguyen Minh Tri, Nguyen Thi My Phuong, Trinh Thi Hong Mo, Thai Thi Thanh Trang, and Phan Nhan. 2026. Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. Alexandria Journal of Veterinary Sciences, 90 (0), 260-270. doi:10.5455/ajvs.320932


Chicago Style

Chuc, Nguyen Thi, Nguyen Minh Tri, Nguyen Thi My Phuong, Trinh Thi Hong Mo, Thai Thi Thanh Trang, and Phan Nhan. "Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy." Alexandria Journal of Veterinary Sciences 90 (2026), 260-270. doi:10.5455/ajvs.320932


MLA (The Modern Language Association) Style

Chuc, Nguyen Thi, Nguyen Minh Tri, Nguyen Thi My Phuong, Trinh Thi Hong Mo, Thai Thi Thanh Trang, and Phan Nhan. "Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy." Alexandria Journal of Veterinary Sciences 90.0 (2026), 260-270. Print. doi:10.5455/ajvs.320932


APA (American Psychological Association) Style

Chuc, N. T., Tri, . N. M., Phuong, . N. T. M., Mo, . T. T. H., Trang, . T. T. T. & Nhan, . P. (2026) Hematological And Biochemical Alterations In Dogs With Canine Parvoviral Enteritis And Treatment Outcomes Following Supportive Therapy. Alexandria Journal of Veterinary Sciences, 90 (0), 260-270. doi:10.5455/ajvs.320932




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Egypt.

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