E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies

Ibrahim A. El-Sanhoury, Samah S. Oda, Samar S. Elblehi, Dina Gad El-Karim.

Abstract
Doxycycline (DOX) is one of widely used antibiotics for treatment of different diseases
in human and animals. This study aimed to evaluate the toxic effects of DOX on different
organs in rats. The experiment was carried out on forty albino rats, they were randomly
divided into four equal groups (10/each): Group 1 served as control group, Group 2 received
doxycycline hyclate 5 mg/Kg Bwt, Group 3 received doxycycline hyclate 25 mg/Kg Bwt and
Group 4 received doxycycline hyclate 50 mg/Kg Bwt. DOX was given intragastrically twice
daily (12 hours interval) for 4 weeks. The results revealed a significant increase in serum
level of liver enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT),
alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT)), increased serum total
protein, albumin and globulins, elevated serum levels of urea and creatinine, in addition to
an increase in cardiac toxicity indicators (lactate dehydrogenase (LDH), and creatine kinase
(CK)-MB enzymes and troponin-I). Also, there were significant increase in levels of
malondialdehyde (MDA) and significant depletion of reduced glutathione (GSH) content
besides various histopathological alterations in liver, kidneys and heart of DOX treated
groups.

Key words: Key Words: Doxycycline, Toxicity, Oxidative stress, Histopathology


 
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How to Cite this Article
Pubmed Style

El-Sanhoury IA, Oda SS, Elblehi SS, El-Karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. 2021; 69(1): 123-130. doi:10.5455/ajvs.50764


Web Style

El-Sanhoury IA, Oda SS, Elblehi SS, El-Karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. http://www.alexjvs.com/?mno=50764 [Access: May 07, 2021]. doi:10.5455/ajvs.50764


AMA (American Medical Association) Style

El-Sanhoury IA, Oda SS, Elblehi SS, El-Karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. 2021; 69(1): 123-130. doi:10.5455/ajvs.50764



Vancouver/ICMJE Style

El-Sanhoury IA, Oda SS, Elblehi SS, El-Karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. (2021), [cited May 07, 2021]; 69(1): 123-130. doi:10.5455/ajvs.50764



Harvard Style

El-Sanhoury, I. A., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. G. (2021) Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS, 69 (1), 123-130. doi:10.5455/ajvs.50764



Turabian Style

El-Sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-Karim. 2021. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. Alexandria Journal of Veterinary Sciences, 69 (1), 123-130. doi:10.5455/ajvs.50764



Chicago Style

El-Sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-Karim. "Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies." Alexandria Journal of Veterinary Sciences 69 (2021), 123-130. doi:10.5455/ajvs.50764



MLA (The Modern Language Association) Style

El-Sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-Karim. "Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies." Alexandria Journal of Veterinary Sciences 69.1 (2021), 123-130. Print. doi:10.5455/ajvs.50764



APA (American Psychological Association) Style

El-Sanhoury, I. A., Oda, . S. S., Elblehi, . S. S. & El-Karim, . D. G. (2021) Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. Alexandria Journal of Veterinary Sciences, 69 (1), 123-130. doi:10.5455/ajvs.50764





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