E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 85
85Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies

Ibrahim A. El-sanhoury, Samah S. Oda, Samar S. Elblehi, Dina Gad El-karim.


Abstract
Doxycycline (DOX) is one of widely used antibiotics for treatment of different diseases
in human and animals. This study aimed to evaluate the toxic effects of DOX on different
organs in rats. The experiment was carried out on forty albino rats, they were randomly
divided into four equal groups (10/each): Group 1 served as control group, Group 2 received
doxycycline hyclate 5 mg/Kg Bwt, Group 3 received doxycycline hyclate 25 mg/Kg Bwt and
Group 4 received doxycycline hyclate 50 mg/Kg Bwt. DOX was given intragastrically twice
daily (12 hours interval) for 4 weeks. The results revealed a significant increase in serum
level of liver enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT),
alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT)), increased serum total
protein, albumin and globulins, elevated serum levels of urea and creatinine, in addition to
an increase in cardiac toxicity indicators (lactate dehydrogenase (LDH), and creatine kinase
(CK)-MB enzymes and troponin-I). Also, there were significant increase in levels of
malondialdehyde (MDA) and significant depletion of reduced glutathione (GSH) content
besides various histopathological alterations in liver, kidneys and heart of DOX treated
groups.

Key words: Key Words: Doxycycline, Toxicity, Oxidative stress, Histopathology


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ibrahim A. El-Sanhoury
Articles by Samah S. Oda
Articles by Samar S. Elblehi
Articles by Dina Gad El-Karim
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

El-sanhoury IA, Oda SS, Elblehi SS, El-karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. 2021; 69(1): 123-130. doi:10.5455/ajvs.50764

Web Style

El-sanhoury IA, Oda SS, Elblehi SS, El-karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. https://www.alexjvs.com/?mno=50764 [Access: March 26, 2025]. doi:10.5455/ajvs.50764

AMA (American Medical Association) Style

El-sanhoury IA, Oda SS, Elblehi SS, El-karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. 2021; 69(1): 123-130. doi:10.5455/ajvs.50764


Vancouver/ICMJE Style

El-sanhoury IA, Oda SS, Elblehi SS, El-karim DG. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS. (2021), [cited March 26, 2025]; 69(1): 123-130. doi:10.5455/ajvs.50764


Harvard Style

El-sanhoury, I. A., Oda, . S. S., Elblehi, . S. S. & El-karim, . D. G. (2021) Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. AJVS, 69 (1), 123-130. doi:10.5455/ajvs.50764


Turabian Style

El-sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-karim. 2021. Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. Alexandria Journal of Veterinary Sciences, 69 (1), 123-130. doi:10.5455/ajvs.50764


Chicago Style

El-sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-karim. "Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies." Alexandria Journal of Veterinary Sciences 69 (2021), 123-130. doi:10.5455/ajvs.50764


MLA (The Modern Language Association) Style

El-sanhoury, Ibrahim A., Samah S. Oda, Samar S. Elblehi, and Dina Gad El-karim. "Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies." Alexandria Journal of Veterinary Sciences 69.1 (2021), 123-130. Print. doi:10.5455/ajvs.50764


APA (American Psychological Association) Style

El-sanhoury, I. A., Oda, . S. S., Elblehi, . S. S. & El-karim, . D. G. (2021) Doxycycline Toxicity in Rats: Clinicobiochemical and Histopathological Studies. Alexandria Journal of Veterinary Sciences, 69 (1), 123-130. doi:10.5455/ajvs.50764




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine
    Alexandria University
    P.O.: 21944
    Abees 10th district, Alexandria
    Egypt.

    email: ajvs@alexu.edu.eg
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use