E-ISSN 2536-9520 | ISSN 1110-2047
 
2024, Vol: 80, Issue: 1
80 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin

Hosny Abd Elfadil, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, Eman M. Amaym.

Abstract
Levofloxacin is considered a strong weapon against several bacterial infections but its serious side effects limit its use. Curcumin, glucosamine hydrochloride (Gls) and vitamin C (Vit C) have strong effective properties. Hence, the study was carried out to assess their protective roles on levofloxacin adverse effects in immature albino rats. Fifty immature male albino rats were divided into five equal groups: I- Control group (received sterile saline solution) orally; II- Levofloxacin group (10mg/kg b.wt) intraperitoneally; III- Levofloxacin + curcumin (200mg/kg b.wt) orally; IV- Levofloxacin + Gls (500mg/kg b.wt) orally; V- Levofloxacin + Vit C (100mg/kg b.wt) intraperitoneally. Rats were euthanized on zero day and 14 days post treatment. The degree of protection was measured using calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and oxidative biomarkers levels. Furthermore, specimens from tendon, joint, ligament and cartilage were collected and subjected to routine histological technique. Levofloxacin significantly decreased Ca concentration and increased P level and ALP activity. Co-administration of curcumin, Gls and/or Vit C restored these biochemical alterations and improved antioxidant defense system. Levofloxacin produced degeneration of collagen fibers of tendons, necrosis of chondrocytes and destruction to lacunae of articular cartilage of joint, degeneration of collagen bundles of ligaments. Curcumin, Gls and/or Vit C were also markedly ameliorated histopathological effect of levofloxacin. In conclusion, curcumin, Gls and/or Vit C exerted protective actions against levofloxacin adverse effects.

Key words: Levofloxacin, Immature rats, Curcumin, Glucosamine hydrochloride, Vitamin C


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Hosny Abd Elfadil
Articles by Ahmed A. Mohamed
Articles by Amany Behairy
Articles by Heba M. Abdel-Ghany
Articles by Eman M. Amaym
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. 2019; 62(1): 182-193. doi:10.5455/ajvs.51618

Web Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. https://www.alexjvs.com/?mno=51618 [Access: December 05, 2023]. doi:10.5455/ajvs.51618

AMA (American Medical Association) Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. 2019; 62(1): 182-193. doi:10.5455/ajvs.51618


Vancouver/ICMJE Style

Elfadil HA, Mohamed AA, Behairy A, Abdel-Ghany HM, Amaym EM. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS. (2019), [cited December 05, 2023]; 62(1): 182-193. doi:10.5455/ajvs.51618


Harvard Style

Elfadil, H. A., Mohamed, . A. A., Behairy, . A., Abdel-Ghany, . H. M. & Amaym, . E. M. (2019) Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. AJVS, 62 (1), 182-193. doi:10.5455/ajvs.51618


Turabian Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. 2019. Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. Alexandria Journal of Veterinary Sciences, 62 (1), 182-193. doi:10.5455/ajvs.51618


Chicago Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. "Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin." Alexandria Journal of Veterinary Sciences 62 (2019), 182-193. doi:10.5455/ajvs.51618


MLA (The Modern Language Association) Style

Elfadil, Hosny Abd, Ahmed A. Mohamed, Amany Behairy, Heba M. Abdel-Ghany, and Eman M. Amaym. "Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin." Alexandria Journal of Veterinary Sciences 62.1 (2019), 182-193. Print. doi:10.5455/ajvs.51618


APA (American Psychological Association) Style

Elfadil, H. A., Mohamed, . A. A., Behairy, . A., Abdel-Ghany, . H. M. & Amaym, . E. M. (2019) Protective Role of Curcumin, Glucosamine and Vitamin C on Oxidative Stress, Biochemical and Histopathological Alterations Induced By Levofloxacin. Alexandria Journal of Veterinary Sciences, 62 (1), 182-193. doi:10.5455/ajvs.51618




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine, Alexandria University
    Edfina, Behaira, Egypt.
    PO.Box: 22758
    Telefax: +20 45 2963526
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use