Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity

Nasser M. El-Sabbagh; Medhat S. Shakweer; Hanan A. Ghetas

doi:10.5455/ajvs.73647

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Original Article
Online Published: 16 Dec 2019

AJVS. 2019; 63(2): 142-155

doi: 10.5455/ajvs.73647

Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity

Nasser M. El-sabbagh, Medhat S. Shakweer, Hanan A. Ghetas.

Abstract
This study was planned to investigate possible positive pharmacological effects of the medicinal plant Moringa oleifera (M oleifera) against the toxic effects of sodium fluoride in sea bream Sparus auratus L exposed to 1/10 LC50 dose of sodium fluoride at 96 hr (6.1 mg/L). Also, the changes in anti-oxidant enzyme activities of superoxide dismutase (SOD) and catalase (CAT) in gills and aspartate transaminase (AST), alanine transaminase (ALT) and Creatinine were studied. In addition, the amelioration of sodium fluoride toxicity by addition of M. oleifera to the ration of exposed fish by the rate of 1% was investigated. The results showed that sodium fluoride decreased total protein in the serum of sea bream. On the other side, the level of AST, ALT and creatinine were increased. SOD and CAT in gills in sodium fluoride exposed group were lower than those in the group where M. oleifera was supplemented. Exposure of sea bream to sodium fluoride for eight weeks resulted in significant changes in mRNA abundance for a limited subset of the analyzed hepatic sea bream genes. GSR mRNA levels decreased in liver upon incubation with sodium fluoride, irrespective to the length of the treatment, whereas the corresponding levels in sea bream fed with M. oleifera were indistinguishable from controls.

Key words: Moringa oleifera, Oxidative stress, sodium fluoride toxicity, sea bream

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Pubmed Style

El-sabbagh NM, Shakweer MS, Ghetas HA. Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. AJVS. 2019; 63(2): 142-155. doi:10.5455/ajvs.73647

Web Style

El-sabbagh NM, Shakweer MS, Ghetas HA. Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. https://www.alexjvs.com/?mno=73647 [Access: May 04, 2025]. doi:10.5455/ajvs.73647

AMA (American Medical Association) Style

El-sabbagh NM, Shakweer MS, Ghetas HA. Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. AJVS. 2019; 63(2): 142-155. doi:10.5455/ajvs.73647

Vancouver/ICMJE Style

El-sabbagh NM, Shakweer MS, Ghetas HA. Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. AJVS. (2019), [cited May 04, 2025]; 63(2): 142-155. doi:10.5455/ajvs.73647

Harvard Style

El-sabbagh, N. M., Shakweer, . M. S. & Ghetas, . H. A. (2019) Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. AJVS, 63 (2), 142-155. doi:10.5455/ajvs.73647

Turabian Style

El-sabbagh, Nasser M., Medhat S. Shakweer, and Hanan A. Ghetas. 2019. Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity. Alexandria Journal of Veterinary Sciences, 63 (2), 142-155. doi:10.5455/ajvs.73647

Chicago Style

El-sabbagh, Nasser M., Medhat S. Shakweer, and Hanan A. Ghetas. "Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity." Alexandria Journal of Veterinary Sciences 63 (2019), 142-155. doi:10.5455/ajvs.73647

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