E-ISSN 2536-9520 | ISSN 1110-2047
 
2023, Vol: 77, Issue: 1
77 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article 


Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats

Amany S. Mawas, Shaimaa Salah, Atef M. Khalil, Mouchira M. Mohi Eldin.

Abstract
Diabetic wound healing impairment remains a major problem in diabetic patients. Medical plants and new products are subjected to have a powerful pharmacological treatment modality on wound healing as sesame oil and Chlorine dioxide gel. Herein, we assessed the contribution of both topical sesame oil and chlorine dioxide gel application on the early healing process of full-thickness wounds in alloxan diabetic rat models. A full-thickness (8mm) artificial uniform skin wounds were created in alloxan-induced diabetic rats (100mg/kg b.w.). Rats were randomly divided into four groups: groups treated with sesame oil and chlorine dioxide gel, non-treated groups served as control non-diabetic, and control diabetic non-treated. Antioxidant activity was evaluated, post healing biopsies were histopathologically and immunohistochemically assessed in addition to measuring inflammatory mediators (TNF-α) by PCR. We found higher blood glucose levels, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea, serum creatinine, and nitric oxide (NO) levels in diabetic groups in comparison to control non-diabetic ones. Low total protein and superoxidase dismutase (SOD) levels in control diabetic non-treated rats than the control nondiabetic and treated groups. A higher level of malondialdehyde (MDA) was detected in the control diabetic group compared to the other treated and control non-diabetic group. Treated wounds showed better contraction percentage, granulation tissue formation, tissue regeneration and lower inflammatory mediator level (TNF-α) compared to control diabetic un-treated wounds. Sesame oil and chlorine dioxide gel applications are able to accelerate wound healing activity in diabetic rats.

Key words: Alloxan, MDA, Rats, Regenerative medicine, Skin, TNF-α.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Amany S. Mawas
Articles by Shaimaa Salah
Articles by Atef M. Khalil
Articles by Mouchira M. Mohi Eldin
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Mawas AS, Salah S, Khalil AM, Eldin MMM. Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. AJVS. 2022; 73(1): 85-96. doi:10.5455/ajvs.76784

Web Style

Mawas AS, Salah S, Khalil AM, Eldin MMM. Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. https://www.alexjvs.com/?mno=76784 [Access: April 30, 2023]. doi:10.5455/ajvs.76784

AMA (American Medical Association) Style

Mawas AS, Salah S, Khalil AM, Eldin MMM. Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. AJVS. 2022; 73(1): 85-96. doi:10.5455/ajvs.76784


Vancouver/ICMJE Style

Mawas AS, Salah S, Khalil AM, Eldin MMM. Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. AJVS. (2022), [cited April 30, 2023]; 73(1): 85-96. doi:10.5455/ajvs.76784


Harvard Style

Mawas, A. S., Salah, . S., Khalil, . A. M. & Eldin, . M. M. M. (2022) Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. AJVS, 73 (1), 85-96. doi:10.5455/ajvs.76784


Turabian Style

Mawas, Amany S., Shaimaa Salah, Atef M. Khalil, and Mouchira M. Mohi Eldin. 2022. Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 85-96. doi:10.5455/ajvs.76784


Chicago Style

Mawas, Amany S., Shaimaa Salah, Atef M. Khalil, and Mouchira M. Mohi Eldin. "Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats." Alexandria Journal of Veterinary Sciences 73 (2022), 85-96. doi:10.5455/ajvs.76784


MLA (The Modern Language Association) Style

Mawas, Amany S., Shaimaa Salah, Atef M. Khalil, and Mouchira M. Mohi Eldin. "Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats." Alexandria Journal of Veterinary Sciences 73.1 (2022), 85-96. Print. doi:10.5455/ajvs.76784


APA (American Psychological Association) Style

Mawas, A. S., Salah, . S., Khalil, . A. M. & Eldin, . M. M. M. (2022) Augmentation of the Diabetic Wound Healing Properties Following Topical Sesame Oil and Chlorine Dioxide Jel Applications in Albino Rats. Alexandria Journal of Veterinary Sciences, 73 (1), 85-96. doi:10.5455/ajvs.76784




Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract & References » doi: 10.5455/ajvs.47290

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

    •
    Most Cited Articles
  • Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken
    Mohamed El-Katcha, Mosad A. Soltan, M. El-badry
    AJVS. 2017; 55(2): 129-145
    » Abstract » doi: 10.5455/ajvs.266925
    Cited : 16 times [Click to see citing articles]

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 12 times [Click to see citing articles]

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232
    Cited : 9 times [Click to see citing articles]

  • Molecular Characterization, Antimicrobial Susceptibility and Salt Tolerance of Aeromonas hydrophila from Fresh, Brackish and Marine fishes
    Basma Dahdouh, Ola Basha, Samy Khalil, Mahmoud Tanekhy
    AJVS. 2016; 48(2): 46-53
    » Abstract & References » doi: 10.5455/ajvs.208107
    Cited : 9 times [Click to see citing articles]

  • Detection of Molecular Characterization of Salmonella enterica isolated from Chicken Meat and Its Products by Using Multiplex PCR
    Heba S. Amin and Abd El-Rahman A. Abd El-Rahman
    AJVS. 2015; 46(1): 155-160
    » Abstract & References » doi: 10.5455/ajvs.196302
    Cited : 7 times [Click to see citing articles]

    •

    Creative Commons License
    This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

    Copyright © 2023 Alexandria Journal of Veterinary Sciences All Rights Reserved. Subject to change without notice from or liability to Alexandria Journal of Veterinary Sciences.
    For best results, please use Internet Explorer or Google Chrome

    Contact Information


    Faculty of Veterinary Medicine, Alexandria University
    Edfina, Behaira, Egypt.
    PO.Box: 22758
    Telefax: +20 45 2963526
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use