E-ISSN 2536-9520 | ISSN 1110-2047
 
2025, Vol: 85
85Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article
Online Published: 04 Aug 2014
 


Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion

Mohamed A. Elnasharty, Mahmoud B. Shoeib.


Abstract
The fact that the splice variant form of choline acetyltransferase (pChAT) is expressed in peripheral organs, including sensory ones, preferentially than the common type (cChAT) is well known. In the current study the possible functional significance of this variant in sensory neurons has been characterized immunohistochemically by investigating the pChAT-immunoreactivity (IR) in the trigeminal ganglia (TG) of the guinea pig. We documented an almost uniform distribution and a considerable number of pChAT-immunoreactivity of all trigeminal neurons. The size of pChAT-IR neurons varied from small to medium-size, although large-sized neurons also observed. Most pChAT reactivity was mainly in the cytoplasm with few number of pChAT-IR neurons had nuclear staining. Double immunofluorescent study showed that a great proportion of substance P (SP)- and calcitonin gene-related peptide (CGRP)-positive trigeminal cells showed pChAT-immunoreactivity, although those with SP outnumbered those with CGRP. The intracellular expression of pChAT (which differs from that of cChAT) probably reflecting a difference in the physiological roles between pChAT and cChAT in ACh production in distinct intracellular compartments. The present data suggest also that pChAT may play roles other than nociception and may be involved in the sensory functions of the TG neurons.

Key words: Trigeminal ganglion; Choline acetyltransferase, Substance P; Calcitonin gene-related peptide; Protein gene product 9.5.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mohamed A. Elnasharty
Articles by Mahmoud B. Shoeib
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Elnasharty MA, Shoeib MB. Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. AJVS. 2014; 42(1): 49-58. doi:10.5455/ajvs.164120

Web Style

Elnasharty MA, Shoeib MB. Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. https://www.alexjvs.com/?mno=164120 [Access: May 04, 2025]. doi:10.5455/ajvs.164120

AMA (American Medical Association) Style

Elnasharty MA, Shoeib MB. Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. AJVS. 2014; 42(1): 49-58. doi:10.5455/ajvs.164120


Vancouver/ICMJE Style

Elnasharty MA, Shoeib MB. Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. AJVS. (2014), [cited May 04, 2025]; 42(1): 49-58. doi:10.5455/ajvs.164120


Harvard Style

Elnasharty, M. A. & Shoeib, . M. B. (2014) Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. AJVS, 42 (1), 49-58. doi:10.5455/ajvs.164120


Turabian Style

Elnasharty, Mohamed A., and Mahmoud B. Shoeib. 2014. Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. Alexandria Journal of Veterinary Sciences, 42 (1), 49-58. doi:10.5455/ajvs.164120


Chicago Style

Elnasharty, Mohamed A., and Mahmoud B. Shoeib. "Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion." Alexandria Journal of Veterinary Sciences 42 (2014), 49-58. doi:10.5455/ajvs.164120


MLA (The Modern Language Association) Style

Elnasharty, Mohamed A., and Mahmoud B. Shoeib. "Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion." Alexandria Journal of Veterinary Sciences 42.1 (2014), 49-58. Print. doi:10.5455/ajvs.164120


APA (American Psychological Association) Style

Elnasharty, M. A. & Shoeib, . M. B. (2014) Expression of Choline Acetyltransferase of the Peripheral Type in the Primary Sensory Neurons of the Guinea Pig Trigeminal Ganglion. Alexandria Journal of Veterinary Sciences, 42 (1), 49-58. doi:10.5455/ajvs.164120




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •
    Most Cited Articles
    Most Cited Articles

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine
    Alexandria University
    P.O.: 21944
    Abees 10th district, Alexandria
    Egypt.

    email: ajvs@alexu.edu.eg
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use