Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Heba-allah M. Saad; Mostafa M. Hassieb; Samah S. Oda; Hossam G. Tohamy; Asmaa F. Khafaga

doi:10.5455/ajvs.264783

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Original Article

AJVS. 2018; 56(1): 102-109

doi: 10.5455/ajvs.264783

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Heba-allah M. Saad, Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, Asmaa F. Khafaga.

Abstract
The present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6th weeks and the 12th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.

Key words: aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degeneration.

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How to Cite this Article

Pubmed Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783

Web Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. https://www.alexjvs.com/?mno=264783 [Access: May 04, 2025]. doi:10.5455/ajvs.264783

AMA (American Medical Association) Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. 2018; 56(1): 102-109. doi:10.5455/ajvs.264783

Vancouver/ICMJE Style

Saad HM, Hassieb MM, Oda SS, Tohamy HG, Khafaga AF. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS. (2018), [cited May 04, 2025]; 56(1): 102-109. doi:10.5455/ajvs.264783

Harvard Style

Saad, H. M., Hassieb, . M. M., Oda, . S. S., Tohamy, . H. G. & Khafaga, . A. F. (2018) Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. AJVS, 56 (1), 102-109. doi:10.5455/ajvs.264783

Turabian Style

Saad, Heba-allah M., Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. 2018. Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits. Alexandria Journal of Veterinary Sciences, 56 (1), 102-109. doi:10.5455/ajvs.264783

Chicago Style

Saad, Heba-allah M., Mostafa M. Hassieb, Samah S. Oda, Hossam G. Tohamy, and Asmaa F. Khafaga. "Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits." Alexandria Journal of Veterinary Sciences 56 (2018), 102-109. doi:10.5455/ajvs.264783

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

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