E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 89
89Current Volume Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Original Article
Online Published: 07 May 2026
 


Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits

Salwa S. Shalan, Sherif I. Ramadan, Hadeel S. El Qaliouby, Basant M. Nagaib, Eman A. Sallam.


Abstract
This study assessed the effects of dietary supplementation with pomegranate peel extract (PPE) and grape seed extract (GSE) on carcass traits, biochemical parameters, hematological indices, and immune gene expression in Alexandria and V-line rabbits. A total of 108 weaned male rabbits (54 per breed) were randomly allocated to three dietary treatments: control, PPE (250 mg/kg), and GSE (250 mg/kg) for 56 days. GSE supplementation significantly increased live body weight in V-line rabbits (2030 g) compared with the control (1525 g), while PPE showed moderate improvements (1772 g). organ weights remained unaffected, with no adverse effects observed on blood biochemical parameters or hematological indices, further confirming the safety of both extracts . PPE improved lipid profiles in V-line rabbits by increasing HDL (26.60 mg/dL) and reducing LDL cholesterol, though triglycerides were elevated (P = 0.00) in Alexandria rabbits. Hematological analysis showed reduced (P = 0.02) white blood cell counts in supplemented groups, indicating decreased systemic inflammation. Gene expression analysis revealed that both extracts significantly upregulated anti-inflammatory IL-10 (4.170 in V-line GSE) and pro-inflammatory TNF-α (3.048 in V-line GSE) compared to control (≈1.000), suggesting balanced immunomodulatory effects. In conclusion, dietary supplementation with PPE and GSE at 250 mg/kg enhanced growth performance and modulated immune responses in rabbits with breed-specific variations, supporting their potential as functional feed additives in sustainable rabbit production systems.

Key words: Grape seed extract, Growth performance, Immune response, Pomegranate peel extract, Rabbits.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Salwa S. Shalan
Articles by Sherif I. Ramadan
Articles by Hadeel S. El Qaliouby
Articles by Basant M. Nagaib
Articles by Eman A. Sallam
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Shalan SS, Ramadan SI, Qaliouby HSE, Nagaib BM, Sallam EA. Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. AJVS. Online First: 07 May, 2026. doi:10.5455/ajvs.316720

Web Style

Shalan SS, Ramadan SI, Qaliouby HSE, Nagaib BM, Sallam EA. Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. https://www.alexjvs.com/?mno=316720 [Access: June 22, 2026]. doi:10.5455/ajvs.316720

AMA (American Medical Association) Style

Shalan SS, Ramadan SI, Qaliouby HSE, Nagaib BM, Sallam EA. Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. AJVS. Online First: 07 May, 2026. doi:10.5455/ajvs.316720


Vancouver/ICMJE Style

Shalan SS, Ramadan SI, Qaliouby HSE, Nagaib BM, Sallam EA. Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. AJVS, [cited June 22, 2026]; Online First: 07 May, 2026. doi:10.5455/ajvs.316720


Harvard Style

Shalan, S. S., Ramadan, . S. I., Qaliouby, . H. S. E., Nagaib, . B. M. & Sallam, . E. A. (0) Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. AJVS, Online First: 07 May, 2026. doi:10.5455/ajvs.316720


Turabian Style

Shalan, Salwa S., Sherif I. Ramadan, Hadeel S. El Qaliouby, Basant M. Nagaib, and Eman A. Sallam. 0. Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. Alexandria Journal of Veterinary Sciences, Online First: 07 May, 2026. doi:10.5455/ajvs.316720


Chicago Style

Shalan, Salwa S., Sherif I. Ramadan, Hadeel S. El Qaliouby, Basant M. Nagaib, and Eman A. Sallam. "Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits." Alexandria Journal of Veterinary Sciences Online First: 07 May, 2026. doi:10.5455/ajvs.316720


MLA (The Modern Language Association) Style

Shalan, Salwa S., Sherif I. Ramadan, Hadeel S. El Qaliouby, Basant M. Nagaib, and Eman A. Sallam. "Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits." Alexandria Journal of Veterinary Sciences Online First: 07 May, 2026. Web. 22 Jun 2026 doi:10.5455/ajvs.316720


APA (American Psychological Association) Style

Shalan, S. S., Ramadan, . S. I., Qaliouby, . H. S. E., Nagaib, . B. M. & Sallam, . E. A. (0) Effect of Pomegranate Peel and Grape Seed Extract on Carcass Traits, Biochemical Parameters, and Immune-Related Gene Expression in Rabbits. Alexandria Journal of Veterinary Sciences, Online First: 07 May, 2026. doi:10.5455/ajvs.316720




Most Viewed Articles
Most Accessed Articles

  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

    •
    Most Downloaded
    Top Downloaded Articles

  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Effect of Excess Fluoride on Reproductive Potentials in Farm Animals (Ovine)
    Ghada H. Abdel-Rahman, Hanaa A. El-Hallawany, Dohreig RA.
    AJVS. 2018; 57(2): 41-57
    » Abstract » doi: 10.5455/ajvs.296364

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract » doi: 10.5455/ajvs.47290

    •

    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Faculty of Veterinary Medicine
    Alexandria University
    P.O.: 21944
    Abees 10th district, Alexandria
    Egypt.

    email: ajvs@alexu.edu.eg
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information