Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study

Samah Eid; Nayera M. El Atfehy; Fatma Amer; Hala N. Tolba; Rehab I. Hamed

doi:10.5455/ajvs.76994

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Original Article

AJVS. 2020; 64(1): 143-153

doi: 10.5455/ajvs.76994

Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study

Samah Eid, Nayera M. El Atfehy, Fatma Amer, Hala N. Tolba, Rehab I. Hamed.

Abstract
Clostridium perfringens (C.perfringens) induced necrotic enteritis (NE) has become a worldwide significant problem in broilers industry. A total of 100 intestinal samples were collected from broilers chickens that demonstrated clinical manifestations and post mortem lesions of Necrotic Enteritis. Bacteriological examination of samples revealed that C. perfringens was isolated from (62/100) 62%. PCR was used to screen the circulating toxigenic subtypes and revealed that 14/20 (70%) of isolates were positive to cpa gene thus belonged to C. perfringens type A. Phenotypic antimicrobial resistance patterns was demonstrated by isolates to lincomycin 51/62(82.26%), ampicillin 45/62 (72.6%), nalidixic acid 43/62(69.35%), and spectinomycin 43/62 (69.35%), respectively. Futhermore, 49/62 (79%) of isolates demonstrated multidrug resistance phenotypes. Experimental study demonstrated better performance indicators in C.perfringens challenged chicks fed on probiotic (Bacillus subtilis) and prebiotic (Mannan Oligosaccharide / MOS) compared to the challenged chicks treated with amoxicillin.
In conclusion, the prevalence of multidrug resistant C.perfringens in infected broilers flocks, signified the need for applying AMR surveillance and raising awareness on the proper use of antibiotics in broilers sector. The promising results of NE prevention associated with feed supplementation by Bacillus subtilis and Mannan Oligosaccharide (MOS) represented an effective alternative to be used in conjunction with good management for prevention of NE rather than its control by antibiotics.

Key words: Bacillus subtilis, Clostridium perfringens, Mannan Oligosaccharides (MOS), Multidrug resistance, PCR.

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Pubmed Style

Eid S, Atfehy NME, Amer F, Tolba HN, Hamed RI. Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. AJVS. 2020; 64(1): 143-153. doi:10.5455/ajvs.76994

Web Style

Eid S, Atfehy NME, Amer F, Tolba HN, Hamed RI. Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. https://www.alexjvs.com/?mno=76994 [Access: May 05, 2025]. doi:10.5455/ajvs.76994

AMA (American Medical Association) Style

Eid S, Atfehy NME, Amer F, Tolba HN, Hamed RI. Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. AJVS. 2020; 64(1): 143-153. doi:10.5455/ajvs.76994

Vancouver/ICMJE Style

Eid S, Atfehy NME, Amer F, Tolba HN, Hamed RI. Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. AJVS. (2020), [cited May 05, 2025]; 64(1): 143-153. doi:10.5455/ajvs.76994

Harvard Style

Eid, S., Atfehy, . N. M. E., Amer, . F., Tolba, . H. N. & Hamed, . R. I. (2020) Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. AJVS, 64 (1), 143-153. doi:10.5455/ajvs.76994

Turabian Style

Eid, Samah, Nayera M. El Atfehy, Fatma Amer, Hala N. Tolba, and Rehab I. Hamed. 2020. Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study. Alexandria Journal of Veterinary Sciences, 64 (1), 143-153. doi:10.5455/ajvs.76994

Chicago Style

Eid, Samah, Nayera M. El Atfehy, Fatma Amer, Hala N. Tolba, and Rehab I. Hamed. "Prevention of Necrotic Enteritis in Broiler Chickens by Prebiotics and Probiotics VS Control by Antibiotics, in Vivo Study." Alexandria Journal of Veterinary Sciences 64 (2020), 143-153. doi:10.5455/ajvs.76994

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APA (American Psychological Association) Style

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