E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats

Aminat O. Ogunfowora, Shakiru A. Salami, Odunayo M. Olumide, Ibiyemi I. Olatunji-Bello, Hussein M. Salahdeen.

Abstract
A key hallmark in diabetes is altered reproductive functions. Kigelia africana is reported to offer therapeutic influence in diabetes. However, literature offers nothing concerning its ability to reverse reproductive complications of diabetes. This study investigates the effect of the ethanolic extract of Kigelia africana (EEKA) on reproductive functions in streptozotocin-induced diabetic male rats. Thirty adult male Wistar rats (150-200 g) were randomly divided into five groups; Group 1 (control) received distilled water (vehicle). Group 2 was treated with 250 mg/kg EEKA. Groups 3, 4, and 5 were made diabetic using streptozotocin. Thereafter, groups 4 and 5 were treated with 250 mg/kg EEK and glibenclamide respectively. Treatments were by oral gavage for six weeks. Bodyweight and blood glucose, liver enzymes and proteins, superoxide dismutase (SOD), malondialdehyde activity (MDA), testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), sperm count, and motility was assessed. EEKA treatment significantly reduced blood glucose in diabetic rats. Serum testosterone was significantly reduced in the diabetic group. However, treatment with EEKA significantly modulated the reduction. EEKA treatment in diabetic rats significantly increased serum LH. Therapeutic EEKA treatment in diabetic rats significantly reversed reduced sperm count and motility. EEKA treatment in the diabetic group reduced MDA activity while significantly enhancing SOD activity. The significant increases in serum alanine aminotransferase and aspartate aminotransferase were significantly reduced with EEKA treatment in the diabetic group. Total protein and albumin were significantly reduced in the diabetic group but significantly reversed with EEKA treatment. Therapeutic administration of EEKA reduced hyperglycemia, enhanced sperm count, motility, and serum testosterone levels in diabetic rats. Phytochemical constituents and robust antioxidant activity of EEKA is involved in the modulation and reversal of diabetes and impaired reproductive parameters.

Key words: Kigelia africana, diabetic male rats, sperm parameters, testosterone, oxidative biomarkers


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Aminat O. Ogunfowora
Articles by Shakiru A. Salami
Articles by Odunayo M. Olumide
Articles by Ibiyemi I. Olatunji-Bello
Articles by Hussein M. Salahdeen
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Ogunfowora AO, Salami SA, Olumide OM, Olatunji-Bello II, Salahdeen HM. Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. AJVS. 2021; 68(1): 22-30. doi:10.5455/ajvs.131039


Web Style

Ogunfowora AO, Salami SA, Olumide OM, Olatunji-Bello II, Salahdeen HM. Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. http://www.alexjvs.com/?mno=131039 [Access: November 18, 2021]. doi:10.5455/ajvs.131039


AMA (American Medical Association) Style

Ogunfowora AO, Salami SA, Olumide OM, Olatunji-Bello II, Salahdeen HM. Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. AJVS. 2021; 68(1): 22-30. doi:10.5455/ajvs.131039



Vancouver/ICMJE Style

Ogunfowora AO, Salami SA, Olumide OM, Olatunji-Bello II, Salahdeen HM. Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. AJVS. (2021), [cited November 18, 2021]; 68(1): 22-30. doi:10.5455/ajvs.131039



Harvard Style

Ogunfowora, A. O., Salami, . S. A., Olumide, . O. M., Olatunji-Bello, . I. I. & Salahdeen, . H. M. (2021) Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. AJVS, 68 (1), 22-30. doi:10.5455/ajvs.131039



Turabian Style

Ogunfowora, Aminat O., Shakiru A. Salami, Odunayo M. Olumide, Ibiyemi I. Olatunji-Bello, and Hussein M. Salahdeen. 2021. Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. Alexandria Journal of Veterinary Sciences, 68 (1), 22-30. doi:10.5455/ajvs.131039



Chicago Style

Ogunfowora, Aminat O., Shakiru A. Salami, Odunayo M. Olumide, Ibiyemi I. Olatunji-Bello, and Hussein M. Salahdeen. "Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats." Alexandria Journal of Veterinary Sciences 68 (2021), 22-30. doi:10.5455/ajvs.131039



MLA (The Modern Language Association) Style

Ogunfowora, Aminat O., Shakiru A. Salami, Odunayo M. Olumide, Ibiyemi I. Olatunji-Bello, and Hussein M. Salahdeen. "Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats." Alexandria Journal of Veterinary Sciences 68.1 (2021), 22-30. Print. doi:10.5455/ajvs.131039



APA (American Psychological Association) Style

Ogunfowora, A. O., Salami, . S. A., Olumide, . O. M., Olatunji-Bello, . I. I. & Salahdeen, . H. M. (2021) Kigelia Africana Stem Bark Extract Treatment Reverses Type 1 Model of Experimental Diabetes and Associated Reproductive Impairments in Male Wistar Rats. Alexandria Journal of Veterinary Sciences, 68 (1), 22-30. doi:10.5455/ajvs.131039





Most Viewed Articles
  • Assessment of The Efficiency of Some Chemical Disinfectants Used in poultry Farms Against Coccidiosis
    Hamed Abdel tawab Samaha, Yasser Nasr Haggag, Mohammed Al sayed Nossair, Heba Mohammed Habib
    AJVS. 2013; 39(1): 82-90
    » Abstract & References

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Molecular Characterization of Listeria Species Isolated from Frozen Fish
    Gaber S. Abdellrazeq, Ayman M. Kamar, Samya M. El-Houshy
    AJVS. 2014; 40(1): 1-15
    » Abstract & References » doi: 10.5455/ajvs.45443

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Most Downloaded
  • Comparative Study of Cellular and Humoral Immune Response to BHV-1 Vaccines in Cattle and Buffalo Calves
    Fayrouz S. Naim; Samy A. Khalil and Helmy A. Torky
    AJVS. 2016; 51(2): 367-373
    » Abstract

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333

  • Using of Polypropylene Mesh for Hernioplasty in Calves
    Mostafa M. kassam, Mahmoud H. Elkammer, Ahmed S. Korittum, Ali A. Abdel-Wahed
    AJVS. 2014; 40(1): 112-117
    » Abstract & References » doi: 10.5455/ajvs.47290

  • Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats
    Sabry M. El-Bahr, Nabil M. Taha, Mahdy A. Korshom, Abd EL-Wahab A. Mandour, Mohamed A. Lebda
    AJVS. 2014; 41(1): 19-27
    » Abstract & References » doi: 10.5455/ajvs.154650

  • Most Cited Articles
  • Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken
    Mohamed El-Katcha, Mosad A. Soltan, M. El-badry
    AJVS. 2017; 55(2): 129-145
    » Abstract » doi: 10.5455/ajvs.266925
    Cited : 11 times [Click to see citing articles]

  • Physiological and Oxidative Stress Biomarkers in the Freshwater Nile Tilapia, Oreochromis niloticus L., exposed to sublethal doses of cadmium
    Ahmed M. EL-Gazzar, Khalid E. Ashry, Yasser S. El-Sayed
    AJVS. 2014; 40(1): 29-43
    » Abstract & References » doi: 10.5455/ajvs.48333
    Cited : 10 times [Click to see citing articles]

  • Molecular Characterization, Antimicrobial Susceptibility and Salt Tolerance of Aeromonas hydrophila from Fresh, Brackish and Marine fishes
    Basma Dahdouh, Ola Basha, Samy Khalil, Mahmoud Tanekhy
    AJVS. 2016; 48(2): 46-53
    » Abstract & References » doi: 10.5455/ajvs.208107
    Cited : 9 times [Click to see citing articles]

  • Growth Performance, Blood Parameters, Immune response and Carcass Traits of Broiler Chicks Fed on Graded Levels of Wheat Instead of Corn without or With Enzyme Supplementation
    Mohamed I. El-Katcha, Mosaad A. Soltan, Hany F. El-Kanwy, EL-syaed R. kawarie
    AJVS. 2014; 40(1): 95-111
    » Abstract & References » doi: 10.5455/ajvs.48232
    Cited : 8 times [Click to see citing articles]

  • Gastrointestinal Parasites of Sheep and Goats in Gwagwalada Area Council, Federal Capital Territory, Abuja, Nigeria; with a special reference to sex, breed and age
    Olorunfemi C. Jegede, Ayegba A. Adejoh, Sylvester S. Obeta, Olutayo D. Olayemi
    AJVS. 2015; 46(1): 170-176
    » Abstract & References » doi: 10.5455/ajvs.177135
    Cited : 6 times [Click to see citing articles]