E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats

Wafaa Elkhrashy, Mohamed Lebda, Abd El-Wahab Mandour, Nabil Taha, Aml Hashem.

Abstract
The current study aimed to explore the protective roles of ginseng against dexamethasone liver devastating effects. Sixty male rats were equally allocated into six groups; G1: control, G2: ginseng aqueous extract (200 mg/kg B.W. orally /4 weeks), G3: dexamethasone (1mg/kg B.W. i.p/one week then decapitated), G4: dexamethasone- withdrawal group (1mg/kg B.W. i.p/one week and decapitated at the end of experiment), G5: dexamethasone ginseng treated group (injected with dexamethasone/one week then treated with ginseng/other 3weeks), and G6: ginseng-dexamethasone-ginseng group (received ginseng/two weeks followed by dexamethasone/one week then ginseng/another week). Dexamethasone significantly increased serum liver enzymatic activities alongside with mild to moderate hepatic vacuolation, and periportal mononuclear infiltration suggesting liver damage. The level of hepatic malondialdehyde (MDA) was elevated markedly with subsequent decline in the reduced glutathione concentration following challenged with dexamethasone. Moreover, the hepatic expression of thioredoxin mRNA transcript was down-regulated while BCL2-associated X protein (Bax) mRNA transcript was up-regulated providing imbalance in antioxidant and apoptosis pathway. Ginseng treatment ameliorated the damaged effects of dexamethasone on the liver as indicated by attenuation of elevated liver enzymatic activities, augmentation the reduced glutathione level, up-regulation thioredoxin mRNA transcription along with down-regulation of Bax mRNA expression in liver tissue. Conclusively, ginseng exerted a protective action on dexamethasone hepatic side effects through anti-apoptotic and antioxidant properties.

Key words: Antioxidant; Apoptosis; Dexamethasone; Glutathione; Hepatic damage; Thioredoxin


 
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How to Cite this Article
Pubmed Style

Elkhrashy W, Lebda M, Mandour AE, Taha N, Hashem A, . Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.


Web Style

Elkhrashy W, Lebda M, Mandour AE, Taha N, Hashem A, . Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats. http://www.alexjvs.com/?mno=47854 [Access: January 31, 2021].


AMA (American Medical Association) Style

Elkhrashy W, Lebda M, Mandour AE, Taha N, Hashem A, . Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.



Vancouver/ICMJE Style

Elkhrashy W, Lebda M, Mandour AE, Taha N, Hashem A, . Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.



Harvard Style

Elkhrashy, W., Lebda, M., Mandour, A. E., Taha, N., Hashem, A. & (0) Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.



Turabian Style

Elkhrashy, Wafaa, Mohamed Lebda, Abd El-Wahab Mandour, Nabil Taha, Aml Hashem, and . 0. Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.



Chicago Style

Elkhrashy, Wafaa, Mohamed Lebda, Abd El-Wahab Mandour, Nabil Taha, Aml Hashem, and . "Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats."



MLA (The Modern Language Association) Style

Elkhrashy, Wafaa, Mohamed Lebda, Abd El-Wahab Mandour, Nabil Taha, Aml Hashem, and . "Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats."



APA (American Psychological Association) Style

Elkhrashy, W., Lebda, M., Mandour, A. E., Taha, N., Hashem, A. & (0) Potential Protective Effect of Ginseng on Dexamethasone-Induced Liver Damage Via Motivation of Anti-Apoptotic and Antioxidant Activities in Rats.





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