The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs

Ayman Atiba and Alaa Ghazy

doi:10.5455/ajvs.177583

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Original Article
Online Published: 15 Apr 2015

AJVS. 2015; 45(1): 6-12

doi: 10.5455/ajvs.177583

The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs

Ayman Atiba And Alaa Ghazy.

Abstract
Burn injury is a major cause of death and disability worldwide. Healing of burn wounds still remains a challenge to modern medicine. The aim of this study was to investigate the effects of Dimethyl sulfoxide (DMSO) on a second-degree burn wounds and compare it with that of silver sulfadiazine (SSD) 1% cream in dogs. A standard deep second-degree burn wound was produced, five dogs, each dog have three groups, DMSO, SSD and control (untreated). The efficacy of treatment was assessed based on the healing percentage of the wound, time to complete wound healing and the degree of inflammation. Wound contraction was higher in the DMSO group than both SSD and the control group. It was significantly higher in the DMSO group than the control group on days 21 and 24 (P < 0.05). The mean times for wound complete closure were 24.4 ± 2.23 and 25.7 ± 2.31 days for DMSO and SSD, respectively, being shorter for DMSO but not significantly (P> 0.05). Clinically, inflammatory reaction was less in DMSO group than the control group. Topical application of DMSO has significant positive effects on the healing of burn wounds in a dog model.

Key words: DMSO, Dog, Burn, Wound-Healing

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Pubmed Style

Ayman Atiba and Alaa Ghazy. The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. AJVS. 2015; 45(1): 6-12. doi:10.5455/ajvs.177583

Web Style

Ayman Atiba and Alaa Ghazy. The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. https://www.alexjvs.com/?mno=177583 [Access: May 03, 2025]. doi:10.5455/ajvs.177583

AMA (American Medical Association) Style

Ayman Atiba and Alaa Ghazy. The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. AJVS. 2015; 45(1): 6-12. doi:10.5455/ajvs.177583

Vancouver/ICMJE Style

Ayman Atiba and Alaa Ghazy. The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. AJVS. (2015), [cited May 03, 2025]; 45(1): 6-12. doi:10.5455/ajvs.177583

Harvard Style

Ayman Atiba and Alaa Ghazy (2015) The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. AJVS, 45 (1), 6-12. doi:10.5455/ajvs.177583

Turabian Style

Ayman Atiba and Alaa Ghazy. 2015. The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. Alexandria Journal of Veterinary Sciences, 45 (1), 6-12. doi:10.5455/ajvs.177583

Chicago Style

Ayman Atiba and Alaa Ghazy. "The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs." Alexandria Journal of Veterinary Sciences 45 (2015), 6-12. doi:10.5455/ajvs.177583

MLA (The Modern Language Association) Style

Ayman Atiba and Alaa Ghazy. "The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs." Alexandria Journal of Veterinary Sciences 45.1 (2015), 6-12. Print. doi:10.5455/ajvs.177583

APA (American Psychological Association) Style

Ayman Atiba and Alaa Ghazy (2015) The Effects of Topical Dimethyle Sulfoxide on Second-Degree Burn Wound Healing in Dogs. Alexandria Journal of Veterinary Sciences, 45 (1), 6-12. doi:10.5455/ajvs.177583

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