E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

Elblehi S. Samar, Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed.

Abstract
The present study was designed to investigate the adverse effects of Cypermethrin (CYP) intoxication on the liver, kidney, brain and heart and the probable alleviating capability of vitamin E and Selenium combination (VE/Se) against such effects. Twenty-four male albino rats were divided randomly into 4 equal groups (6 rats each), CYP-treated rats received CYP (4.67 mg/kg bwt equals 1/10 LD50) orally once daily, CYP +VE/Se-treated rats were injected subcutaneously with 0.2 ml/kg bwt Viteselen®15 twice weekly with concurrent daily administration of CYP once daily, VE/Se-treated rats and control group. After 60 days treatment all rats were euthanized. CYP induced significant increase in serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), urea, creatinine and malondialdhyde (MDA) levels and a significant reduction in reduced glutathione (GSH) level. Also, CYP revealed marked degenerative and necrotic alterations in liver, kidneys, brain and heart. Conversely, treatment with VE/Se combination improved CYP-induced oxidative damage and the histopathological alterations of these organs. Results indicated that CYP exerts significant harmful effects. And the concurrent administration of VE/Se partly reduced these detrimental effects.

Key words: Cypermethrin- vitamin E and Selenium- albino rats.


 
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How to Cite this Article
Pubmed Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. 2015; 47(1): 158-165. doi:10.5455/ajvs.203149


Web Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. http://www.alexjvs.com/?mno=203149 [Access: November 27, 2020]. doi:10.5455/ajvs.203149


AMA (American Medical Association) Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. 2015; 47(1): 158-165. doi:10.5455/ajvs.203149



Vancouver/ICMJE Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. (2015), [cited November 27, 2020]; 47(1): 158-165. doi:10.5455/ajvs.203149



Harvard Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed (2015) Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS, 47 (1), 158-165. doi:10.5455/ajvs.203149



Turabian Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. 2015. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 47 (1), 158-165. doi:10.5455/ajvs.203149



Chicago Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. "Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 47 (2015), 158-165. doi:10.5455/ajvs.203149



MLA (The Modern Language Association) Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed. "Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 47.1 (2015), 158-165. Print. doi:10.5455/ajvs.203149



APA (American Psychological Association) Style

Elblehi S. Samar , Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed (2015) Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 47 (1), 158-165. doi:10.5455/ajvs.203149





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