Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

Elblehi S. Samar; Oda S. Samah; Tohamy G. Hossam; Elmanakhly M. El-sayed

doi:10.5455/ajvs.203149

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Original Article
Online Published: 30 Oct 2015

AJVS. 2015; 47(1): 158-165

doi: 10.5455/ajvs.203149

Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats

Elblehi S. Samar, Oda S. Samah, Tohamy G. Hossam, Elmanakhly M. El-sayed.

Abstract
The present study was designed to investigate the adverse effects of Cypermethrin (CYP) intoxication on the liver, kidney, brain and heart and the probable alleviating capability of vitamin E and Selenium combination (VE/Se) against such effects. Twenty-four male albino rats were divided randomly into 4 equal groups (6 rats each), CYP-treated rats received CYP (4.67 mg/kg bwt equals 1/10 LD50) orally once daily, CYP +VE/Se-treated rats were injected subcutaneously with 0.2 ml/kg bwt Viteselen®15 twice weekly with concurrent daily administration of CYP once daily, VE/Se-treated rats and control group. After 60 days treatment all rats were euthanized. CYP induced significant increase in serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), urea, creatinine and malondialdhyde (MDA) levels and a significant reduction in reduced glutathione (GSH) level. Also, CYP revealed marked degenerative and necrotic alterations in liver, kidneys, brain and heart. Conversely, treatment with VE/Se combination improved CYP-induced oxidative damage and the histopathological alterations of these organs. Results indicated that CYP exerts significant harmful effects. And the concurrent administration of VE/Se partly reduced these detrimental effects.

Key words: Cypermethrin- vitamin E and Selenium- albino rats.

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How to Cite this Article

Pubmed Style

Samar ES, Samah OS, Hossam TG, El-sayed EM. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. 2015; 47(1): 158-165. doi:10.5455/ajvs.203149

Web Style

Samar ES, Samah OS, Hossam TG, El-sayed EM. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. https://www.alexjvs.com/?mno=203149 [Access: May 06, 2025]. doi:10.5455/ajvs.203149

AMA (American Medical Association) Style

Samar ES, Samah OS, Hossam TG, El-sayed EM. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. 2015; 47(1): 158-165. doi:10.5455/ajvs.203149

Vancouver/ICMJE Style

Samar ES, Samah OS, Hossam TG, El-sayed EM. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS. (2015), [cited May 06, 2025]; 47(1): 158-165. doi:10.5455/ajvs.203149

Harvard Style

Samar, E. S., Samah, . O. S., Hossam, . T. G. & El-sayed, . E. M. (2015) Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. AJVS, 47 (1), 158-165. doi:10.5455/ajvs.203149

Turabian Style

Samar, Elblehi S., Oda S. Samah, Tohamy G. Hossam, and Elmanakhly M. El-sayed. 2015. Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 47 (1), 158-165. doi:10.5455/ajvs.203149

Chicago Style

Samar, Elblehi S., Oda S. Samah, Tohamy G. Hossam, and Elmanakhly M. El-sayed. "Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats." Alexandria Journal of Veterinary Sciences 47 (2015), 158-165. doi:10.5455/ajvs.203149

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Samar, E. S., Samah, . O. S., Hossam, . T. G. & El-sayed, . E. M. (2015) Protective Effect of Vitamin E and Selenium Combination on Cypermethrin-Induced Toxicity in Male Rats. Alexandria Journal of Veterinary Sciences, 47 (1), 158-165. doi:10.5455/ajvs.203149

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