E-ISSN 2536-9520 | ISSN 1110-2047
 

Original Article 


EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION

IJEOMA RITA UDEGBUNAM, FRANK UGOCHUKWU OGBODO, CHUKWUDUM AUGUSTINE ONUBA, NNAMDI HENRY OKEREKE, TOOCHUKWU HENRY EZEOBIALU, SUNDAY OSITADINMA UDEGBUNAM.

Abstract
The study evaluated the effect of constant rate infusion of tramadol-xylazine and pentazocine-xylazine on pain in dogs undergoing digital amputation. Twelve mongrel used for the study were randomly assigned to four groups (n=3). Group 1 received loading dose (LD) Xylazine (1mg/kg IV) and Pentobarbitone sodium (Na) (30mg/kg IV) [LD-XP] prior to digital amputation (DA).Group 2 received LD-XP andXylazine (1mg/kg/hr) by constant rate infusion (CRI IV) prior to DA. Group 3 received LD Xylazine (1mg/kg IV), Pentobarbitone Na (30mg/kg IV), CRI Xylazine (1mg/kg/hr) and Tramadol (1mg/kg/hr) prior to DA. Group 4 received LD-XP, CRI Xylazine (1mg/kg/hr) and CRI Pentazocine (1mg/kg/hr) prior to DA. Results of the pain score evaluation showed that at 1, 3, 6 and 24 hours post-surgery (PS), group 4 had the lowest (p<0.05) pain score followed by group 3. Group 4 animals had a significantly (p<0.05) higher heart rate and pulse rate values at 3 and 120 hours. The respiratory rate of group 4 was significantly higher (p<0.05) when compared with the other groups at 3 and 24 hours. It was concluded that CRI pentazocine-xylazine provided better analgesia in the dog DA model.

Key words: pain, tramadol, analgesia, multi-modal, pentazocine, xylazine


 
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How to Cite this Article
Pubmed Style

UDEGBUNAM IR, OGBODO FU, ONUBA CA, OKEREKE NH, EZEOBIALU TH, UDEGBUNAM SO, . EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.


Web Style

UDEGBUNAM IR, OGBODO FU, ONUBA CA, OKEREKE NH, EZEOBIALU TH, UDEGBUNAM SO, . EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION. http://www.alexjvs.com/?mno=28363 [Access: January 17, 2021].


AMA (American Medical Association) Style

UDEGBUNAM IR, OGBODO FU, ONUBA CA, OKEREKE NH, EZEOBIALU TH, UDEGBUNAM SO, . EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.



Vancouver/ICMJE Style

UDEGBUNAM IR, OGBODO FU, ONUBA CA, OKEREKE NH, EZEOBIALU TH, UDEGBUNAM SO, . EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.



Harvard Style

UDEGBUNAM, I. R., OGBODO, F. U., ONUBA, C. A., OKEREKE, N. H., EZEOBIALU, T. H., UDEGBUNAM, S. O. & (0) EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.



Turabian Style

UDEGBUNAM, IJEOMA RITA, FRANK UGOCHUKWU OGBODO, CHUKWUDUM AUGUSTINE ONUBA, NNAMDI HENRY OKEREKE, TOOCHUKWU HENRY EZEOBIALU, SUNDAY OSITADINMA UDEGBUNAM, and . 0. EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.



Chicago Style

UDEGBUNAM, IJEOMA RITA, FRANK UGOCHUKWU OGBODO, CHUKWUDUM AUGUSTINE ONUBA, NNAMDI HENRY OKEREKE, TOOCHUKWU HENRY EZEOBIALU, SUNDAY OSITADINMA UDEGBUNAM, and . "EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION."



MLA (The Modern Language Association) Style

UDEGBUNAM, IJEOMA RITA, FRANK UGOCHUKWU OGBODO, CHUKWUDUM AUGUSTINE ONUBA, NNAMDI HENRY OKEREKE, TOOCHUKWU HENRY EZEOBIALU, SUNDAY OSITADINMA UDEGBUNAM, and . "EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION."



APA (American Psychological Association) Style

UDEGBUNAM, I. R., OGBODO, F. U., ONUBA, C. A., OKEREKE, N. H., EZEOBIALU, T. H., UDEGBUNAM, S. O. & (0) EFFECT OF CONSTANT RATE INFUSION OF TRAMADOL-XYLAZINE AND PENTAZOCINE XYLAZINE ON ACUTE PAIN RESPONSE IN XYLAZINE-PENTOBARBITONE ANAESTHESIZED DOGS UNDERGOING DIGITAL AMPUTATION.





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