E-ISSN 2536-9520 | ISSN 1110-2047
 
2026, Vol: 91
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Original Article
Online Published: 27 Sep 2026
 


Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice

Fatma Samir, Mostafa Kassem, Ramadan Abd Elwaheed, Hoda Atef, Ahmed Koriem.


Abstract
Delayed wound healing is a frequent complication in cancer patients, particularly following chemotherapy, highlighting the need for safe therapeutic strategies that enhance tissue repair. This study evaluated the wound-healing potential of a topical Cinnamon–Clove extract in healthy, tumor-bearing, and doxorubicin-treated tumor-bearing mice using a full-thickness excisional wound model. Wounds were treated with either Carbopol (control) or Cinnamon–Clove extract (30 mg/mL) for 17 days. Wound contraction was assessed by digital planimetry, while tissue regeneration was evaluated histologically. The extract exhibited moderate antioxidant activity, with a DPPH radical scavenging activity of 28.04%. In healthy and tumor-bearing mice, Cinnamon–Clove treatment did not significantly alter wound closure but improved tissue remodeling, as demonstrated by enhanced fibroblast proliferation, collagen organization, re-epithelialization, and restoration of skin architecture. In contrast, doxorubicin markedly impaired wound healing, whereas topical Cinnamon–Clove extract significantly accelerated wound closure, achieving 98.83 ± 1.17% closure compared with 85.80 ± 9.35% in chemotherapy controls by Day 17. Histopathological analysis confirmed enhanced collagen deposition, fibroblast activity, epidermal regeneration, and overall tissue organization in extract-treated wounds. These findings demonstrate that topical Cinnamon–Clove extract improves tissue regeneration and effectively attenuates chemotherapy-induced impairment of wound healing. The extract may represent a promising adjunctive topical therapy for managing delayed wound healing associated with cytotoxic chemotherapy.

Key words: Doxorubicin; Tumor-bearing mice; Tissue regeneration; Phytotherapy; Oxidative stress


 
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How to Cite this Article
Pubmed Style

Samir F, Kassem M, Elwaheed RA, Atef H, Koriem A. Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. AJVS. 2026; 91(0): 490-498. doi:10.5455/ajvs.330681

Web Style

Samir F, Kassem M, Elwaheed RA, Atef H, Koriem A. Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. https://www.alexjvs.com/?mno=330681 [Access: October 18, 2026]. doi:10.5455/ajvs.330681

AMA (American Medical Association) Style

Samir F, Kassem M, Elwaheed RA, Atef H, Koriem A. Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. AJVS. 2026; 91(0): 490-498. doi:10.5455/ajvs.330681


Vancouver/ICMJE Style

Samir F, Kassem M, Elwaheed RA, Atef H, Koriem A. Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. AJVS. (2026), [cited October 18, 2026]; 91(0): 490-498. doi:10.5455/ajvs.330681


Harvard Style

Samir, F., Kassem, . M., Elwaheed, . R. A., Atef, . H. & Koriem, . A. (2026) Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. AJVS, 91 (0), 490-498. doi:10.5455/ajvs.330681


Turabian Style

Samir, Fatma, Mostafa Kassem, Ramadan Abd Elwaheed, Hoda Atef, and Ahmed Koriem. 2026. Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. Alexandria Journal of Veterinary Sciences, 91 (0), 490-498. doi:10.5455/ajvs.330681


Chicago Style

Samir, Fatma, Mostafa Kassem, Ramadan Abd Elwaheed, Hoda Atef, and Ahmed Koriem. "Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice." Alexandria Journal of Veterinary Sciences 91 (2026), 490-498. doi:10.5455/ajvs.330681


MLA (The Modern Language Association) Style

Samir, Fatma, Mostafa Kassem, Ramadan Abd Elwaheed, Hoda Atef, and Ahmed Koriem. "Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice." Alexandria Journal of Veterinary Sciences 91.0 (2026), 490-498. Print. doi:10.5455/ajvs.330681


APA (American Psychological Association) Style

Samir, F., Kassem, . M., Elwaheed, . R. A., Atef, . H. & Koriem, . A. (2026) Cinnamon–Clove emulsion Improves Tissue Regeneration and Attenuates Chemotherapy-Impaired Full-Thickness Wound Healing in Tumor-Bearing Mice. Alexandria Journal of Veterinary Sciences, 91 (0), 490-498. doi:10.5455/ajvs.330681




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Alexandria University
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    Abees 10th district, Alexandria
    Egypt.

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