Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain

Aymen Mabrouk; Amina Sakly; Feiza Mnasria; Lobna Ezzi

doi:10.5455/ajvs.51335

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Original Article
Online Published: 17 May 2021

AJVS. 2021; 69(2): 113-119

doi: 10.5455/ajvs.51335

Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain

Aymen Mabrouk, Amina Sakly, Feiza Mnasria, Lobna Ezzi.

Abstract
Lead (Pb) is a pervasive industrial and environmental pollutant that seriously impairs the central nervous system, primarily by disrupting the redox balance. The current research was conducted to explore the possible beneficial action of thymoquinone (TQ), the main active component in Nigella sativa seed volatile oil, against brain oxidative stress and DNA damage caused by Pb. Wistar adult male rats were treated with TQ (5 mg/kg/day, per os) and/or Pb (2000 ppm of Pb acetate in drinking water) for five weeks. Results showed that Pb exposure significantly increased metal content, malondialdehyde concentration and DNA damage (assessed by comet assay), but significantly decreased the level of reduced glutathione and the activities of catalase, glutathione peroxidase, and superoxide dismutase in the brain tissue. These detrimental effects Pb-induced, except tissue metal accumulation, were significantly improved by TQ supplementation. In conclusion, our findings suggested that TQ might be a promising therapeutic alternative in Pb neurotoxicity.

Key words: Thymoquinone, lead, genotoxicity, oxidative stress, brain, rat.

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How to Cite this Article

Pubmed Style

Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-119. doi:10.5455/ajvs.51335

Web Style

Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. https://www.alexjvs.com/?mno=51335 [Access: May 04, 2025]. doi:10.5455/ajvs.51335

AMA (American Medical Association) Style

Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. 2021; 69(2): 113-119. doi:10.5455/ajvs.51335

Vancouver/ICMJE Style

Mabrouk A, Sakly A, Mnasria F, Ezzi L. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS. (2021), [cited May 04, 2025]; 69(2): 113-119. doi:10.5455/ajvs.51335

Harvard Style

Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. AJVS, 69 (2), 113-119. doi:10.5455/ajvs.51335

Turabian Style

Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. 2021. Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-119. doi:10.5455/ajvs.51335

Chicago Style

Mabrouk, Aymen, Amina Sakly, Feiza Mnasria, and Lobna Ezzi. "Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain." Alexandria Journal of Veterinary Sciences 69 (2021), 113-119. doi:10.5455/ajvs.51335

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Mabrouk, A., Sakly, . A., Mnasria, . F. & Ezzi, . L. (2021) Thymoquinone Improved Lead-Induced DNA Damage and Oxidative Stress in Rat Brain. Alexandria Journal of Veterinary Sciences, 69 (2), 113-119. doi:10.5455/ajvs.51335

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