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Original Article
Online Published: 02 Oct 2025
 


The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats

Reham Waheeb, Samah S. Oda, Hoda Elkhenany, Mayada Marouf, Alshimaa A. Abd-elmoneam, Mahmoud M. Elmaghraby.


Abstract
The current study aimed at evaluating the efficacy of gossypol–bovine serum albumin nanoparticles (Gossy-BSA NPs) as an antifertility compound and to assess its effect on hepatorenal function in rats. For this purpose, eighteen adult male albino rats were allocated into 2 groups: treated rats (n=9), received single bilateral intra-testicular injection of 2mg Gossy-BSA NPs, and control rats (n=9), received normal saline by the same route. Quality of epididymal semen, selected biochemical parameters, testosterone level and the histopathology of testes, epididymis, liver and kidney were estimated at 2-, 4-, and 6-weeks following treatment. Gossy-BSA NPs treatment induced deteriorated semen quality related parameters evidenced by a significant (P < 0.01) reduction in sperm count, motility, and also reduced serum level of testosterone. Serum alanine aminotransferase (ALT) significantly elevated (P < 0.05) at weeks 2 and 6 in treated rats relative to controls. Other parameters such as albumin, bilirubin, urea, creatinine, and CRP showed normal values in treated rats. Histopathological analysis revealed progressive degeneration in seminiferous epithelium and loss of germ cells over the experiment duration. Liver and kidney showed mild to moderate inflammatory changes involving congestion and inflammatory cells infiltration. These findings indicate that Gossy-BSA NPs has antifertility properties with tolerable systemic effects, however further studies are needed to assess their long-term safety and efficacy.

Key words: Gossypol nanoparticles, antifertility, hepatorenal effects, testosterone, semen quality, histopathology.


 
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How to Cite this Article
Pubmed Style

Waheeb R, Oda SS, Elkhenany H, Marouf M, Abd-elmoneam AA, Elmaghraby MM. The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. AJVS. 2025; 87(0): 259-272. doi:10.5455/ajvs.278875

Web Style

Waheeb R, Oda SS, Elkhenany H, Marouf M, Abd-elmoneam AA, Elmaghraby MM. The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. https://www.alexjvs.com/?mno=278875 [Access: June 27, 2026]. doi:10.5455/ajvs.278875

AMA (American Medical Association) Style

Waheeb R, Oda SS, Elkhenany H, Marouf M, Abd-elmoneam AA, Elmaghraby MM. The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. AJVS. 2025; 87(0): 259-272. doi:10.5455/ajvs.278875


Vancouver/ICMJE Style

Waheeb R, Oda SS, Elkhenany H, Marouf M, Abd-elmoneam AA, Elmaghraby MM. The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. AJVS. (2025), [cited June 27, 2026]; 87(0): 259-272. doi:10.5455/ajvs.278875


Harvard Style

Waheeb, R., Oda, . S. S., Elkhenany, . H., Marouf, . M., Abd-elmoneam, . A. A. & Elmaghraby, . M. M. (2025) The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. AJVS, 87 (0), 259-272. doi:10.5455/ajvs.278875


Turabian Style

Waheeb, Reham, Samah S. Oda, Hoda Elkhenany, Mayada Marouf, Alshimaa A. Abd-elmoneam, and Mahmoud M. Elmaghraby. 2025. The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. Alexandria Journal of Veterinary Sciences, 87 (0), 259-272. doi:10.5455/ajvs.278875


Chicago Style

Waheeb, Reham, Samah S. Oda, Hoda Elkhenany, Mayada Marouf, Alshimaa A. Abd-elmoneam, and Mahmoud M. Elmaghraby. "The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats." Alexandria Journal of Veterinary Sciences 87 (2025), 259-272. doi:10.5455/ajvs.278875


MLA (The Modern Language Association) Style

Waheeb, Reham, Samah S. Oda, Hoda Elkhenany, Mayada Marouf, Alshimaa A. Abd-elmoneam, and Mahmoud M. Elmaghraby. "The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats." Alexandria Journal of Veterinary Sciences 87.0 (2025), 259-272. Print. doi:10.5455/ajvs.278875


APA (American Psychological Association) Style

Waheeb, R., Oda, . S. S., Elkhenany, . H., Marouf, . M., Abd-elmoneam, . A. A. & Elmaghraby, . M. M. (2025) The Antifertility Effects of Gossypol–Bovine Serum Albumin Nanoparticles and its Hepatorenal Impact in Male Rats. Alexandria Journal of Veterinary Sciences, 87 (0), 259-272. doi:10.5455/ajvs.278875




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    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Abees 10th district, Alexandria
    Egypt.

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