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2026, Vol: 89
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Original Article 


The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid

Amal A. Awad, Suad A. Saeed, Najah A. Mohamad, Abd El-salam F. El-sawy, Hanan H. Abd-el Hafeez, Zeynab Kh. El-maddawy.


Abstract
Our study examined the effects on rat reproductive parameters of Flunixin Meglumine (FM) and its concomitant treatment with Alpha Lipoic Acid (ALA). FM was given to male rats with or without ALA at a concentration of 2.5 and 5 mg./kg. bwt, while ALA was in a dose level of 100mg/ kg body weight. Along with semen characteristics include total sperm count, total sperm abnormalities and progressive sperm motility, the index weights of the accessory sex glands, epididymis, and testis were examined. 72 adult male albino rats were used in this study. During the fourth and eighth weeks from the beginning of the experiment, the index weights of the testis didn’t significantly change in any of the treatment groups during comparison with the control group. However, the index weight of the epididymis significantly reduced in the group that was treated with FM at a dose level of 5 mg/kg in the fourth week, whereas there was a notable increase in the group that received FM at the same dosage concomitant with ALA. In terms of semen properties, progressive sperm motility significantly decreased in the fourth and eighth weeks after FM treatment at a dose level of 5 mg/kg. The FM-treated groups' total sperm count significantly decreased during both time periods, whereas the ALA-only group's sperm count significantly increased on 8th week of the experiment. At both times, the FM-treated groups had a significantly increased total number of sperm abnormalities. In summary, the administration of FM for 14 consecutive days had a negative impact on reproductive indicators. Co-administration of ALA, however, mitigated some of these effects, indicating that ALA may have a protective function in maintaining reproductive function when FM is present.

Key words: Flunixin Meglumine, Alpha-Lipoic Acid, rats, reproductive parameters, semen characteristics


 
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How to Cite this Article
Pubmed Style

Awad AA, Saeed SA, Mohamad NA, El-sawy AEF, Hafeez HHA, El-maddawy ZK. The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. AJVS. 2025; 87(0): 61-72. doi:10.5455/ajvs.270603

Web Style

Awad AA, Saeed SA, Mohamad NA, El-sawy AEF, Hafeez HHA, El-maddawy ZK. The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. https://www.alexjvs.com/?mno=270603 [Access: June 26, 2026]. doi:10.5455/ajvs.270603

AMA (American Medical Association) Style

Awad AA, Saeed SA, Mohamad NA, El-sawy AEF, Hafeez HHA, El-maddawy ZK. The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. AJVS. 2025; 87(0): 61-72. doi:10.5455/ajvs.270603


Vancouver/ICMJE Style

Awad AA, Saeed SA, Mohamad NA, El-sawy AEF, Hafeez HHA, El-maddawy ZK. The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. AJVS. (2025), [cited June 26, 2026]; 87(0): 61-72. doi:10.5455/ajvs.270603


Harvard Style

Awad, A. A., Saeed, . S. A., Mohamad, . N. A., El-sawy, . A. E. F., Hafeez, . H. H. A. & El-maddawy, . Z. K. (2025) The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. AJVS, 87 (0), 61-72. doi:10.5455/ajvs.270603


Turabian Style

Awad, Amal A., Suad A. Saeed, Najah A. Mohamad, Abd El-salam F. El-sawy, Hanan H. Abd-el Hafeez, and Zeynab Kh. El-maddawy. 2025. The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. Alexandria Journal of Veterinary Sciences, 87 (0), 61-72. doi:10.5455/ajvs.270603


Chicago Style

Awad, Amal A., Suad A. Saeed, Najah A. Mohamad, Abd El-salam F. El-sawy, Hanan H. Abd-el Hafeez, and Zeynab Kh. El-maddawy. "The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid." Alexandria Journal of Veterinary Sciences 87 (2025), 61-72. doi:10.5455/ajvs.270603


MLA (The Modern Language Association) Style

Awad, Amal A., Suad A. Saeed, Najah A. Mohamad, Abd El-salam F. El-sawy, Hanan H. Abd-el Hafeez, and Zeynab Kh. El-maddawy. "The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid." Alexandria Journal of Veterinary Sciences 87.0 (2025), 61-72. Print. doi:10.5455/ajvs.270603


APA (American Psychological Association) Style

Awad, A. A., Saeed, . S. A., Mohamad, . N. A., El-sawy, . A. E. F., Hafeez, . H. H. A. & El-maddawy, . Z. K. (2025) The Impact of Flunixin Meglumine and Alpha-Lipoic Acid on Male Reproductive Parameters and the Protective Potential of Alpha-Lipoic Acid. Alexandria Journal of Veterinary Sciences, 87 (0), 61-72. doi:10.5455/ajvs.270603




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    About Alexandria Journal of Veterinary Sciences

    The Alexandria Journal of Veterinary Sciences (AJVS) Official Journal of Faculty of Veterinary Medicine, Alexandria University   ISSN: 1110-204 ... Read more.



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    Abees 10th district, Alexandria
    Egypt.

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